Martina Pagliuca

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Sirs: A 27-year-old woman with a history of Hashimoto’s thyroiditis presented with psychotic symptoms and myoclonus. Four months earlier, her relatives had noticed myoclonic jerks in the four limbs and depression. During the following weeks, the patient also manifested visual hallucinations and generalized tonic-clonic seizures. In addition, progressive(More)
Background Penile carcinoma is a rare disease, with incidence rates varying in the range of 1–10 cases per 100,000 men depending on ethnicity, geographic area, cultural background and social habits [1,2]. Tumorigenesis of penile carcinoma is governed by a complex interplay of multiple causative factors. These include initiating agents, such as tobacco(More)
Bladder cancer is a major cause of cancer-related mortality, with an estimated 74,000 new cases and 16,000 deaths in the United States in 2015. In patients with metastatic disease, vinflunine and taxanes are the most widely used chemotherapy agents in the second-line setting after failure of platinum-based treatment. Cyclophosphamide has been used in(More)
Background: Cabazitaxel is a second-generation taxane that is approved for use with concomitant low dose daily prednisone in metastatic castration resistant prostate cancer (mCRPC) after docetaxel failure. Since the role of daily corticosteroids in improving cabazitaxel efficacy or ameliorating its safety profile has not been adequately investigated so far,(More)
Chemotherapy agents for patients with metastatic castration-resistant prostate cancer (mCRPC) include docetaxel and cabazitaxel. Although docetaxel is approved in the first-line treatment setting, a few studies have shown that selected patients can benefit from docetaxel rechallenge.We, here, report the case of a heavily pretreated mCRPC patient who(More)
BACKGROUND The development of squamous cell carcinoma of the lower lip is an interesting model of photocarcinogenesis because of the structural and topographic characteristics of the lips. The purpose of this study was to evaluate the expression of immunohistochemical markers on the lips of patients with lower lip squamous cell carcinoma (LLSCC), compared(More)
RATIONALE PSA responses have been associated with a survival benefit in patients treated with enzalutamide in retrospective analyses. PATIENT CONCERNS However the prognostic value of PSA declines in highly pretreated patients receiving enzalutamide remains to be defined. DIAGNOSES AND INTERVENTATIONS Medical records of patients with documented mCRPC(More)
INTRODUCTION While the majority of the vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) inhibitors currently used for the therapy of metastatic renal cell carcinoma (mRCC) are small molecule agents inhibiting multiple targets, monoclonal antibodies are inhibitors of specific targets, which may decrease off-target effects(More)
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