Martina Marková

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Epidemiological and experimental studies indicate that non-steroidal anti-inflammatory drugs play role in the prevention of human neoplasia including mammary gland cancer. In this study, tumour suppressive effects of a selective inhibitor of cyclooxygenase-2 (COX-2) rofecoxib in the prevention of N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis(More)
The aim of the present study was to evaluate serum copper concentration changes in patients with benign cysts or carcinomas of ovary, and to compare these concentrations with the normal reference serum copper levels. Patients included in the study were as follows: benign ovarian cyst cases (n = 19), endometrial cyst cases (n = 5), ovarian carcinoma cases (n(More)
The aim of the study is to determine the concentration of blood serum zinc of women with ovarian tumors. The patients included in the study are as follows: 15 women with benign ovarian cysts, 5 with endometrial cysts and 5 with ovarian carcinoma. The control group consists of 157 healthy women whose serum zinc concentration was 13.50 +/- 2.60 mmol/L. We(More)
The question of effects of long-term melatonin (MEL) administration have not yet been explained sufficiently, especially its metabolic consequences in young persons and animals. The aim of the present study was to analyze the effects of MEL given during prolonged time (for 3 months) and chronically (for 6 months) at the dose of 4 µg/mL of tap water, on the(More)
Experimental data on the influence of separate protein feeding by giving milk cassein at different hours of the day and night, apart from the energy-supplying food, to young rats, showed that protein is best utilized by the organism when given durins the dark period of the day. The results obtained are discussed in relation to the coefficients of protein(More)
Purine analogs are often used for conditioning preceding allogeneic hematopoietic stem cell transplantation (HCT). We prospectively tested fludarabine (Flu) 40 mg/m2/day × 5 days vs cladribine (Clad) 10 mg/m2/day × 5 days plus oral busulfan (1 mg/kg q6 h × 2 days) and total body irradiation 200 cGy in 32 recipients of matched sibling and unrelated donor(More)
Over a period of 20 months we investigated 1366 vaginal specimens from pregnant women for GBS (group B streptococci) carrier in three microscopic patterns, evaluated by Nugent score system. More frequently we isolated GBS in group I intermedia (score 4-6)--20.8%, (when Lactobacillus spp. is missing--67.4%, without or associated with other nonanaerobic(More)