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hERG1 channels modulate integrin signaling to trigger angiogenesis and tumor progression in colorectal cancer
Angiogenesis is a potential target for cancer therapy. We identified a novel signaling pathway that sustains angiogenesis and progression in colorectal cancer (CRC). This pathway is triggered by β1Expand
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Changes in the expression of the glutamate transporter EAAT3/EAAC1 in health and disease
Excitatory amino acid transporters (EAATs) are high-affinity Na+-dependent carriers of major importance in maintaining glutamate homeostasis in the central nervous system. EAAT3, the humanExpand
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GPNA inhibits the sodium-independent transport system l for neutral amino acids
Abstractl-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine transporter ASCT2, although it is known that it also inhibits other sodium-dependent amino acid transporters. In aExpand
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Glutamine stimulates mTORC1 independent of the cell content of essential amino acids
Glutamine and leucine are important mTORC1 modulators, although their roles are not precisely defined. In HepG2 and HeLa cells glutamine-free incubation lowers mTORC1 activity, although cell leucineExpand
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Towards a metabolic therapy of cancer?
It is increasingly appreciated that cancer cells must be endowed with specific metabolic adaptations to support enhanced growth and to ensure survival under stressful conditions. On the other hand,Expand
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Dependence on glutamine uptake and glutamine addiction characterize myeloma cells: a new attractive target.
The importance of glutamine (Gln) metabolism in multiple myeloma (MM) cells and its potential role as a therapeutic target are still unknown, although it has been reported that human myeloma cellExpand
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Shape-Related Toxicity of Titanium Dioxide Nanofibres
Titanium dioxide (TiO2) nanofibres are a novel fibrous nanomaterial with increasing applications in a variety of fields. While the biological effects of TiO2 nanoparticles have been extensivelyExpand
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The non-proteinogenic amino acids l-methionine sulfoximine and dl-phosphinothricin activate mTOR
Abstractl-Methionine sulfoximine (MSO) and dl-Phosphinothricin (PPT), two non-proteinogenic amino acids known as inhibitors of Glutamine Synthetase, cause a dose-dependent increase in theExpand
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The potential of inhibiting glutamine uptake as a therapeutic target for multiple myeloma
Multiple myeloma (MM) is characterized by the accumulation of malignant plasma cells into the bone marrow (BM). Despite the recent introduction of new drugs, MM remains an incurable disease with highExpand
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