Martina Baumann

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The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety of culture conditions, but also results in genomic and phenotypic instability. To investigate the relative contribution of genomic and epigenetic modifications towards phenotype evolution, comprehensive genome(More)
In this paper the reliable operation of a three-phase three-switch buck-type PWM unity power factor rectifier with integrated boost output stage under heavily unbalanced mains, i.e. mains voltage unbalance, loss of one phase, short circuit of two phases or earth fault of one phase is investigated theoretically and experimentally. The analytical calculation(More)
— In this paper the active DC side current balancing of parallel connected three-phase buck-type rectifier systems is investigated using space vector calculus. Modulation schemes for the parallel connection are derived from the switching state sequences known for a single system and are comparatively evaluated by digital simulation. The independent current(More)
The 6th International Conference on Analysis of Microbial Cells at the Single Cell Level, held in Retz, Austria from 19 to 22 July 2015, brought together experts from different areas working with bacterial, yeast and mammalian cell systems. The conference highlighted the importance of dissecting cell behaviour down to the single cell level, as analysis of(More)
The aging population and accompanying diseases like diabetes resulted in an increased occurrence of chronic wounds. Topical wound treatment with antimicrobial agents to inhibit bacterial invasion and promote wound healing is often associated with difficulties. Here, we investigated the potential of succinyl chitosan (SC)-carboxymethyl cellulose (CMC)(More)
The production of recombinant proteins for biotherapeutic use is a multibillion dollar industry, which has seen continual growth in recent years. In order to produce the best protein with minimal cost and time, selection methods are utilized during the cell line development process in order to select for the most desirable clonal cell line from a(More)
Site-specific Recombinase Mediated Cassette Exchange (RMCE) enables the transfer of the gene of interest (GOI) into pre-selected genomic locations with defined expression properties. For the generation of recombinant production cell lines this has the advantage that screening for high transcription rates at the genome integration site would be required only(More)
Chitosan hydrogels are gaining increasing interest for biomedical applications due to attractive properties such as biocompatibility. In order to replace toxic chemical cross-linkers for hydrogel formation, we investigated the cross-linking potential of laccase oxidized phenolics. HPLC-TOF-MS and ATR-FTIR demonstrated that phenolics were bond to glucosamine(More)
— In this paper the parallel connection of two three-phase buck-type unity power factor recti-fier systems is investigated experimentally for a 10kW DSP-controlled prototype. There, a space vector modulation scheme is employed which shows all advantages of interleaved operation of the two systems. Three control schemes for active DC-side current balancing(More)
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