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PURPOSE Electrical stimulation of the anterior nucleus of the thalamus appears to be effective against seizures in animals and humans. As the optimal stimulation settings remain elusive, we studied the effects of different stimulation parameters against pilocarpine induced seizures and status epilepticus (SE). METHODS Adult rats had electrodes implanted(More)
Intra-cranial electroencephalographic recordings are increasingly employed in mice because of the availability of genetically manipulated mouse models. Currently, dental acrylic and anchoring screws are used to cement implanted electrodes. This technique works well for adult animals but often encounters difficulty when employed in young mice because their(More)
A number of reports have suggested that some cases of multiple personality disorder might be due to temporal lobe epileptic discharges. We have administered a structured interview, the Dissociative Disorders Interview Schedule, to 20 subjects with multiple personality disorder, 20 with complex partial seizures, and 28 neurologic controls. Subjects also(More)
Treatment for epilepsy depends largely on seizure frequency reported by patients through their seizure diaries. However, patients may be unaware of some of their seizures, which may lead to incomplete diary data, impacting on appropriate treatment plans. The purpose of this study was to quantify awareness of seizures in patients admitted to an epilepsy(More)
OBJECTIVE High frequency oscillations (HFOs) have recently been recorded in epilepsy patients and proposed as possible novel biomarkers of epileptogenicity. Investigation of additional HFO characteristics that correlate with the clinical manifestation of seizures may yield additional insights for delineating epileptogenic regions. To that end, this study(More)
We examined intra-cranial electroencephalographic activity in a mouse model of global hypoxia in an attempt to explore the pathophysiology underlying hypoxic seizures. Mice between the ages of 22 and 41 days underwent repeated hypoxic challenges, and their behavioral and electroencephalographic activities were monitored continuously before, during and after(More)
  • Daniel D Beck, Michael R Dohm, Theodore Garland, Jr, Aurelio Ramirez-Bautista, Charles H Lowe +17 others
  • 2008
A principal goal of previous studies has been to determine what behavioral, ecological, and evolutionary factors influence performance measures such as endurance and aerobic capacity. For example, Garland (1994) documented considerable variation in treadmill endurance capacities among 57 lizard species/subspecies. About half of this variation could be(More)
OBJECTIVE Subclinical rhythmic electrographic discharges of adults (SREDA) is currently considered a benign EEG pattern of uncertain significance. The underlying cortical sources and generating mechanisms are unknown. We performed a source localization analysis of SREDA with the aim of better understanding this unusual EEG pattern. METHODS Multiple(More)
BACKGROUND The neuropathology of hypoglycemia and its mechanisms have been well studied. However, the physiopathogenesis of hypoglycemia-related seizures has escaped elucidation. Various animal models reportedly show "seizures" when rendered hypoglycemic, however, correlation with the electroencephalogram (EEG) is inconsistent. In order to characterize the(More)