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Phylogenomics of the Reproductive Parasite Wolbachia pipientis wMel: A Streamlined Genome Overrun by Mobile Genetic Elements
Genetic analysis of the wMel genome further supports the hypothesis that mitochondria share a common ancestor with the α-Proteobacteria, but shows little support for the grouping of mitochondria with species in the order Rickettsiales. Expand
The Genome Sequence of the Malaria Mosquito Anopheles gambiae
Analysis of the PEST strain of A. gambiae revealed strong evidence for about 14,000 protein-encoding transcripts, and prominent expansions in specific families of proteins likely involved in cell adhesion and immunity were noted. Expand
A simple, fast, and accurate method of phylogenomic inference
An automated pipeline for phylogenomic analysis (AMPHORA) is developed that overcomes the existing bottlenecks limiting large-scale protein phylogenetic inference and demonstrates its high throughput capabilities and high quality results. Expand
Macronuclear Genome Sequence of the Ciliate Tetrahymena thermophila, a Model Eukaryote
The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology. Like other ciliates, this species has separate germline and soma functions that are embodied by distinctExpand
A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea
The results strongly support the need for systematic ‘phylogenomic’ efforts to compile a phylogeny-driven ‘Genomic Encyclopedia of Bacteria and Archaea’ in order to derive maximum knowledge from existing microbial genome data as well as from genome sequences to come. Expand
The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria
Several chromosomally encoded proteins that may contribute to pathogenicity—including haemolysins, phospholipases and iron acquisition functions—and numerous surface proteins that might be important targets for vaccines and drugs are found. Expand
Phylogenomic analysis of bacterial and archaeal sequences with AMPHORA2
AMPHORA2 is an automated phylogenomic inference tool that can be used for high-throughput, high-quality genome tree reconstruction and metagenomic phylotyping and has several major enhancements and new functions. Expand
Three Genomes from the Phylum Acidobacteria Provide Insight into the Lifestyles of These Microorganisms in Soils
Combining the genomic evidence with available culture traits, it is postulate that cells of these isolates are long-lived, divide slowly, exhibit slow metabolic rates under low-nutrient conditions, and are well equipped to tolerate fluctuations in soil hydration. Expand
Rapid Evolution of Enormous, Multichromosomal Genomes in Flowering Plant Mitochondria with Exceptionally High Mutation Rates
A pair of species within the genus Silene have evolved the largest known mitochondrial genomes, coinciding with extreme changes in mutation rate, recombination activity, and genome structure.
Comparative Genomics of Emerging Human Ehrlichiosis Agents
Analysis identified proteins potentially involved in vacuole confinement of the Anaplasmataceae, a life cycle involving a hematophagous vector, vertebrate pathogenesis, human pathogenesis and lack of transovarial transmission, which provide significant insights into the biology of these obligate intracellular pathogens. Expand