Martin Wegner

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We present the General Game Playing system Centurio. Centurio is a Java-based player featuring different strategies based on Monte Carlo Tree Search extended by techniques borrowed from Upper Confidence bounds applied to Trees as well as Answer Set Programming (for single-player games). Centurio’s Monte Carlo Tree Search is accomplished in a massively(More)
The hallmarks of Alzheimer's disease (AD) are characterized by cognitive decline and behavioral changes. The most prominent brain region affected by the progression of AD is the hippocampal formation. The pathogenesis involves a successive loss of hippocampal neurons accompanied by a decline in learning and memory consolidation mainly attributed to an(More)
More than 20 years ago the amyloid precursor protein (APP) was identified as the precursor protein of the Aβ peptide, the main component of senile plaques in brains affected by Alzheimer's disease (AD). The pathophysiology of AD, characterized by a massive loss of synapses, cognitive decline, and behavioral changes was in principle attributed to the(More)
In this paper we address the issue of change after deployment in safety-critical embedded system applications. Our goal is to substitute lab-based verification with in-field formal analysis to determine whether an update may be safely applied. This is challenging because it requires an automated process able to handle multiple viewpoints such as functional(More)
Synaptic release sites are characterized by exocytosis-competent synaptic vesicles tightly anchored to the presynaptic active zone (PAZ) whose proteome orchestrates the fast signaling events involved in synaptic vesicle cycle and plasticity. Allocation of the amyloid precursor protein (APP) to the PAZ proteome implicated a functional impact of APP in(More)
BACKGROUND AND PURPOSE The treatment quality of pencil beam scanned (PBS) proton therapy to mobile tumour treatments can be compromised due to interplay effects. The aim of this work is to systematically evaluate the effectiveness of rescanning for liver tumour treatments for a commercial PBS delivery system. MATERIALS AND METHODS Plans were calculated to(More)
Recently there is a number of scenarios such as vehicle platooning, UAV swarms and cooperative robots, where a group of autonomous entities needs to make joint decisions to operate effectively. Distributed agreement protocols can play a key role to establish a common view on context parameters and to coordinate joint actions. Due to the harsh environmental(More)
This simulation study investigated the dosimetric effectiveness and treatment efficiency of surface motion guided gating of pencil beam scanning (PBS) proton therapy for liver tumour treatments. Dedicated 4D dose calculations were performed for simulating gated treatments using 4DCT data for six patients derived from 4DMRI (4DCT(MRI)). Surface motion as a(More)