Martin Strauch

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BACKGROUND Cells dynamically adapt their gene expression patterns in response to various stimuli. This response is orchestrated into a number of gene expression modules consisting of co-regulated genes. A growing pool of publicly available microarray datasets allows the identification of modules by monitoring expression changes over time. These time-series(More)
We have developed a new computational framework for merging odor response data sets from heterogeneous studies, creating a consensus metadatabase, the database of odor responses (DoOR). As a result, we obtained a functional atlas of all available odor responses in Drosophila melanogaster. Both the program and the data set are freely accessible and(More)
The calcium-imaging technique allows us to record movies of brain activity in the antennal lobe of the fruitfly <i>Drosophila melanogaster</i>, a brain compartment where information about odors is processed. For signal processing that scales up with the growing data sizes in imaging, we have developed an approximate Principal Component Analysis (PCA) for(More)
An odorant stimulus given to a bee elicits a characteristic combinatorial pattern of activity in neuronal units called glomeruli. These patterns can be measured by optical imaging, however detecting and identifying the glomeruli is a laborious task and prone to errors. Here, we present an image analysis pipeline for the automatic detection and(More)
Calcium-imaging enables us to record movies of brain activity from the antennal lobe, a region of the honeybee brain responsible for processing odor information. Here, we present a matrix factorisation framework to automatically detect the neural units in this region and to accurately estimate their signals. Based on a non-negative mixture model, the(More)
Neuronal plasticity allows an animal to respond to environmental changes by modulating its response to stimuli. In the honey bee (Apis mellifera), the biogenic amine octopamine plays a crucial role in appetitive odor learning, but little is known about how octopamine affects the brain. We investigated its effect in the antennal lobe, the first olfactory(More)
We developed an integrative approach for discovering gene modules, i.e. genes that are tightly correlated under several experimental conditions and applied it to a three-dimensional Arabidopsis thaliana microarray dataset. The dataset consists of approximately 23000 genes responding to 9 abiotic stress conditions at 6-9 different points in time. Our(More)
  • Eduardo Hatano, Ahmed M. Saveer, Felipe Borrero-Echeverry, Martin Strauch, Ali Zakir, Marie Bengtsson +5 others
  • 2015
Plants under herbivore attack release volatiles that attract natural enemies, and herbivores in turn avoid such plants. Whilst herbivore-induced plant volatile blends appeared to reduce the attractiveness of host plants to herbivores, the volatiles that are key in this process and particularly the way in which deterrence is coded in the olfactory system are(More)
Cancer cells and non-cancer cells differ in their metabolism and they emit distinct volatile compound profiles, allowing to recognise cancer cells by their scent. Insect odorant receptors are excellent chemosensors with high sensitivity and a broad receptive range unmatched by current gas sensors. We thus investigated the potential of utilising the fruit(More)
In the antennal lobe, a dedicated olfactory center of the honeybee brain, odours are encoded as activity patterns of coding units, the so-called glomeruli. Optical imaging with calcium-sensitive dyes allows us to record these activity patterns and to gain insight into olfactory information processing in the brain. We introduce ImageBee, a plugin for the(More)