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The application of the pharmacophore concept to design new drugs is discussed. The focus is on the application of computer-assisted drug design methods (CADD) in the discovery of new leads.
Selectins play a key role in the inflammatory cascade. The interaction with their physiological ligands containing the tetrasaccharide sialyl Lewisx (sLex) leads to the recruitment of leukocytes from… (More)
Noscapine, a natural alkaloid, has never been used as a parent scaffold in chiral induction. The first examples of noscapinoid compounds as efficient catalysts in asymmetric synthesis are now… (More)
Although animal lectins usually show a high degree of specificity for glycan structures, their single-site binding affinities are typically weak, a drawback which is often compensated in biological… (More)
Cette divulgation concerne des composes glycomimetiques antagonistes des E-selectines de formule (I) et des compositions pharmaceutiques comprenant au moins un de ceux-ci. Les composes selon la… (More)