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The aim of this study was to investigate the role of cytosolic calcium for renin gene expression in juxtaglomerular cells. For this purpose, we used the immortalized juxtaglomerular mouse cell line As4.1. To increase cytosolic calcium concentration, we treated the cells with thapsigargin and cyclopiazonic acid, inhibitors of the endoplasmatic reticulum Ca-(More)
—We present a prototype implementation and simulation based evaluation of a recently proposed novel approach for Byzantine fault-tolerant and self-stabilizing clock distribution in multi-synchronous GALS architectures. Fault-tolerant clock generation and clock distribution is a mandatory prerequisite for highly dependable multicore processors and(More)
Diese Übersichtsarbeit befasst sich mit der Diagnostik der beiden Großgefäßvaskulitiden Takayasu-Arteriitis und Riesenzellarteriitis mit Hauptaugenmerk auf das nuklearmedizinische Verfahren der Positronen-Emissions-Tomographie mit 18F-Fluordeoxyglykose (18F-FDG-PET) und die Kombination mit der Computertomographie (18F-FDG-PET/CT). Trotz der technischen(More)
Imatinib failure and response to dasatinib in a patient with chronic myeloid leukemia in blast crisis and a novel, nine-nucleotide BCR-ABL insertion mutation In chronic phase chronic myeloid leukemia (CML), the BCR-ABL kinase inhibitor imatinib leads to complete cytogenetic responses in the majority of cases. Resistance towards imatinib is associated with(More)
Most patients with peripheral arterial disease suffer from arteriosclerosis, the prevalence of which increases with age. In some of these patients, however, the ischemic symptoms are not caused by stenotic arteriosclerosis, but by large vessel giant cell arteritis (LV-GCA), a disease also predominantly affecting patients of the older generation. Identifying(More)
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