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The aim of this study was to investigate the role of cytosolic calcium for renin gene expression in juxtaglomerular cells. For this purpose, we used the immortalized juxtaglomerular mouse cell line As4.1. To increase cytosolic calcium concentration, we treated the cells with thapsigargin and cyclopiazonic acid, inhibitors of the endoplasmatic reticulum Ca-(More)
—We present a prototype implementation and simulation based evaluation of a recently proposed novel approach for Byzantine fault-tolerant and self-stabilizing clock distribution in multi-synchronous GALS architectures. Fault-tolerant clock generation and clock distribution is a mandatory prerequisite for highly dependable multicore processors and(More)
Imatinib failure and response to dasatinib in a patient with chronic myeloid leukemia in blast crisis and a novel, nine-nucleotide BCR-ABL insertion mutation In chronic phase chronic myeloid leukemia (CML), the BCR-ABL kinase inhibitor imatinib leads to complete cytogenetic responses in the majority of cases. Resistance towards imatinib is associated with(More)
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