Martin Schwarzer

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BACKGROUND AND AIMS The egg protein ovalbumin (OVA) belongs to six most frequent food allergens. We investigated how thermal processing influences its ability to induce allergic symptoms and immune responses in mouse model of food allergy. METHODOLOGY/PRINCIPAL FINDINGS Effect of increased temperature (70°C and 95°C) on OVA secondary structure was(More)
This paper presents the effect of the loop nest splitting source code optimization on worst-case execution time (WCET). Loop nest splitting minimizes the number of executed if-statements in loop nests of multimedia applications. It identifies iterations where all if-statements are satisfied and splits the loop nest such that if-statements are not executed(More)
In most animal species, juvenile growth is marked by an exponential gain in body weight and size. Here we show that the microbiota of infant mice sustains both weight gain and longitudinal growth when mice are fed a standard laboratory mouse diet or a nutritionally depleted diet. We found that the intestinal microbiota interacts with the somatotropic(More)
BACKGROUND Reduced microbial diversity has been associated with inflammatory bowel disease (IBD) and probiotic bacteria have been proposed for its prevention and/or treatment. Nevertheless, comparative studies of strains of the same subspecies for specific health benefits are scarce. Here we compared two Bifidobacterium longum ssp. longum strains for their(More)
For the worst-case execution time (WCET) analysis, especially loops are an inherent source of unpredictability and loss of precision. This is caused by the difficulty to obtain safe and tight information on the number of iterations executed by a loop in the worst case. In particular, data-dependent loops whose iteration counts depend on function parameters(More)
BACKGROUND Disturbances in the intestinal microbial community (i.e. dysbiosis) or presence of the microbes with deleterious effects on colonic mucosa has been linked to the pathogenesis of inflammatory bowel diseases. However the role of microbiota in induction and progression of ulcerative colitis (UC) has not yet been fully elucidated. METHODS Three(More)
A decrease in the abundance and biodiversity of intestinal bacteria within the Firmicutes phylum has been associated with inflammatory bowel disease (IBD). In particular, the anti-inflammatory bacterium Faecalibacterium prausnitzii, member of the Firmicutes phylum and one of the most abundant species in healthy human colon, is underrepresented in the(More)
The Lactobacillus casei strain, LOCK 0919, is intended for the dietary management of food allergies and atopic dermatitis (LATOPIC(®) BIOMED). The use of a probiotic to modulate immune responses is an interesting strategy for solving imbalance problems of gut microflora that may lead to various disorders. However, the exact bacterial signaling mechanisms(More)
The genus Lactobacillus belongs to a large heterogeneous group of low G + C Gram-positive anaerobic bacteria, which are frequently used as probiotics. The health-beneficial effects, in particular the immunomodulation effect, of probiotics depend on the strain and dose used. Strain variations may be related to diversity of the cell surface architecture of(More)
Embedded software spends most of its execution time in loops. To allow a precise static WCET analysis, each loop iteration should, in theory, be represented by an individual calling context. However, due to the enormous analysis times of real-world applications, this approach is not feasible and requires a reduction of the analysis complexity by limiting(More)