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The L10P single nucleotide polymorphism (SNP) is located in the signal sequence of the transforming growth factor β1 (TGFβ1) gene. The proline-encoding (Pro-) allele of this SNP has been associated with an increased breast cancer risk, which has been attributed to the elevated secretion of this TGFβ1 variant observed in vitro and in male subjects. Here we(More)
  • D Holstead Jones, Tomoki Nakashima, Otto H Sanchez, Ivona Kozieradzki, Svetlana V Komarova, Ildiko Sarosi +12 others
  • 2006
Bone metastases are a frequent complication of many cancers that result in severe disease burden and pain. Since the late nineteenth century, it has been thought that the microenvironment of the local host tissue actively participates in the propensity of certain cancers to metastasize to specific organs, and that bone provides an especially fertile 'soil'.(More)
R apid progress in trauma care occurs when the results of translational research are promptly integrated into clinical practice. Experience with a high volume of severely injured casualties expedites the process. 1 Historically, these conditions have converged during times of conflict, improving the care of combat casualties and subsequently that of(More)
BACKGROUND The Jun N-terminal kinase (JNK) signaling pathway has been implicated in cell proliferation and apoptosis, but its function seems to depend on the cell type and inducing signal. In T cells, JNK has been implicated in both antigen-induced activation and apoptosis. RESULTS We generated mice lacking the JNK2 isozymes. The mutant mice were healthy(More)
  • Eitan Shaulian, Martin Schreiber, Fabrice Piu, Michelle Beeche, Erwin F Wagner, Michael Karin
  • 2000
The mammalian UV response results in rapid and dramatic induction of c-jun. Induction of a protooncogene, normally involved in mitogenic responses, by a genotoxic agent that causes growth arrest seems paradoxical. We now provide an explanation for the role of c-Jun in the UV response of mouse fibroblasts. c-Jun is necessary for cell-cycle reentry of(More)
—In this work we present an approach for the paral-lelization of hyperbolic simulations on shared-memory architec-tures running on fully-adaptive grids. We tackle the parallelization problem with a dynamic sub-tree split-and join-approach by running computations on those split sub-trees in parallel using lightweight tasks. The traversal of sub-trees created(More)
Metastasis is the major cause of carcinoma-induced death, but mechanisms involved are poorly understood. Metastasis crucially involves epithelial-to-mesenchymal transition (EMT), causing loss of epithelial polarity. Here we identify Annexin A1 (AnxA1), a protein with important functions in intracellular vesicle trafficking, as an efficient suppressor of EMT(More)
The present paper studies solvers for partial differential equations that work on dynamically adaptive grids stemming from spacetrees. Due to the underlying tree formalism, such grids efficiently can be decomposed into connected grid regions (clusters) on-the-fly. A graph on those clusters classified according to their grid invariancy, workload, multi-core(More)