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VIDEO ABSTRACT Extracellular recordings have elucidated spatial neural representations without identifying underlying microcircuits. We labeled neurons juxtacellularly in medial entorhinal cortex of freely moving rats with a friction-based, pipette-stabilization system. In a linear maze novel to the animals, spatial firing of superficial layer neurons was(More)
The tissue availability of active glucocorticoids (cortisol in humans) depends on their rate of synthesis from cholesterol, downstream metabolism, excretion and interconversion. The latter is mediated by the 11β-hydroxysteroid dehydrogenases (11βHSDs). In this review, we summarize the features of the two isoenzymes, 11βHSD1 and 11βHSD2, and current(More)
Virtually nothing is known about the activity of morphologically identified neurons in freely moving mammals. Here we describe stabilization and positioning techniques that allow juxtacellular recordings from labeled single neurons in awake, freely moving animals. This method involves the use of a friction-based device that allows stabilization of the(More)
This paper details a free surface method using an explicit time stepping scheme for use in z-coordinate ocean models. One key property that makes the method especially suitable for climate simulations is its very stable numerical time stepping scheme, which allows for the use of a long density time step, as commonly employed with coarse-resolution rigid-lid(More)
Coinductive definitions, such as that of an infinite stream, may often be described by elegant logic programs, but ones for which SLD-refutation is of no value as SLD-derivations fall into infinite loops. Such definitions give rise to questions of lazy corecursive derivations and parallelism, as execution of such logic programs can have both recursive and(More)
— We present a description and initial results of a computer code that coevolves fuzzy logic rules to play a two-sided zero-sum competitive game. It is based on the TEMPO Military Planning Game that has been used to teach resource allocation to over 20,000 students over the past 40 years. No feasible algorithm for optimal play is known. The coevolved rules,(More)
We present a description and initial results of a computer code that coevolves Fuzzy Logic rules to play a two-sided zero-sum competitive game. It is based on the TEMPO Military Planning Game that has been used to teach resource allocation to over 20,000 students over the past 40 years. No feasible algorithm for optimal play is known. The coevolved rules,(More)