Martin Sénécal

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We estimated the impact of rotavirus-associated gastroenteritis (RGE) on health-related quality of life of children and parents as background for economic evaluation of rotavirus vaccines. A total of 186 new cases of RGE in children <36 months old were recruited from physician and pediatric clinics and followed up for 2 weeks. Our results show that RGE(More)
The objective was to assess persistence with antihypertensive therapy (AHT) and discontinuation patterns in patients newly dispensed different antihypertensive drug classes in a natural Canadian population-based setting. Hypertensive patients initiating AHT monotherapy were included in this 3-year retrospective cohort study (N=21 326) using the Saskatchewan(More)
OBJECTIVE The quadrivalent human papillomavirus (HPV) vaccine is effective against HPV types responsible for 90% of anogenital warts. This study estimated the quality of life lost to genital warts using the EQ-5D, a generic instrument widely used for applications in economic analyses. The findings are described in terms that are more specific to individuals(More)
BACKGROUND Regardless of their HIV status, injection drug users (IDUs) are at increased risk of developing active tuberculosis (TB) if they have latent TB infection (LTBI). We quantified the prevalence and predictors of LTBI and level of adherence to medical evaluation in a population of IDUs in Montreal. METHODS Participants were recruited from an(More)
We reviewed prognostic studies for patients treated with renal replacement therapy by using an electronic database and bibliographic review for 1990 to 1998. Using the inclusion criteria of English language, adult patients, primary article, minimum 50 patients, primary focus on prognostic factors, and mortality outcome, 104 articles were identified. The 104(More)
BACKGROUND Although statins are widely used to reduce low density lipoprotein cholesterol (LDL-C), there is little information about patient profiles, treatment patterns and goal achievement among statin-treated patients in Canada. OBJECTIVES To assess the profile of statin-treated patients and to determine whether they are achieving recommended targets(More)
BACKGROUND Current assessments of the burden of rotavirus (RV)-related gastroenteritis are needed to evaluate the potential benefits of RV immunization interventions. The objective of the present study was to characterize the burden of RV gastroenteritis among children presenting in outpatient settings with gastroenteritis. METHODS Between January and(More)
Given the recent evolution of therapeutic trends, the frequency and determinants of multiclass-resistant HIV infection in the modern combination highly active antiretroviral therapy (HAART) era are less well understood. In this study, the authors characterize the epidemiology of antiretroviral multiclass resistance among HAART-naïve patients enrolled in a(More)
OBJECTIVE Several randomized controlled trials indicate that a low density lipoprotein cholesterol (LDL-C) target <2.0 mmol/L is appropriate for individuals at high risk of coronary artery disease (CAD). Recently released Canadian lipid management guidelines (2006) have incorporated this evidence into their recommendations. A cross-sectional study of(More)