Martin Radermacher

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BACKGROUND A prospective analysis was performed to characterize the angiographic appearance, natural course and prognosis of serous pigment epithelial detachments (PEDs) in elderly patients. The aim was to differentiate PEDs according to their angiographic characteristics and to analyze the specific clinical, visual and morphologic course of the different(More)
OBJECTIVE To examine the phenomenon of a prolonged choroidal filling phase (PCFP) as seen on fluorescein and indocyanine green (ICG) angiography in patients with early age-related macular disease (AMD). METHODS One hundred eyes of consecutive patients with early AMD were studied. Patchy and slow choroidal filling in early fluorescein and distinct areas of(More)
Background. A prospective analysis was performed to characterize the angiographic appearance, natural course and prognosis of serous pigment epithelial detachments (PEDs) in elderly patients. The aim was to differentiate PEDs according to their angiographic characteristics and to analyze the specific clinical, visual and morphologic course of the different(More)
BACKGROUND Lipofuscin is the main fluorophore of the human fundus. Because lipofuscin is the result of the accumulation of metabolic debris in pigmentepithelial cells (RPE), the autofluorescence can be interpreted as a clinical sign for the metabolic activity of the RPE. In order to get informations of RPE-function in different types of late AMD, the(More)
PURPOSE To describe a German family with clinical and genetic evidence of autosomal dominant North Carolina macular dystrophy. METHODS Twenty-six individuals from a five-generation family from northern Germany were investigated clinically. In addition, we performed genetic linkage analyses using polymorphic markers from proximal 6q. RESULTS The affected(More)
Purpose. A prospective longitudinal study was initiated to analyze the correlation between the prognosis for the second eyes of patients with unilateral late exudative AMD and the disease phenotype. Methods. Of the187 patients with unilateral late exudative AMD recruited, 130 (69.5%) had predominantly classic CNV without pigment epithelium detachment (PED)(More)
Hintergrund: Es wurde untersucht, ob die Laser-scanning-Tomographie zu einer 3-dimensionalen Darstellung, Vermessung und Verlaufsbeobachtung von Pigmentepithel-Abhebungen (PE-Abhebungen) bei AMD geeignet ist. Fluoreszenzangiographische und klinische Befunde wurden mit tomographischen Befunden korreliert. Patienten und Methode: Mit dem(More)
BACKGROUND A pigment epithelial detachment (PED) is an exudative manifestation of late age-related macular degeneration (AMD). Its long-term unfavourable prognosis is influenced by the association of a neovascular membrane. Seemingly identical PEDs in ophthalmoscopy can be further differentiated by fluorescein and indocyanine green angiography. The purpose(More)
Es gibt noch wenig aktuelle deutsche Daten, die beschreiben, wie die Standardtherapie der neovaskulären altersabhängigen Makuladegeneration (nAMD), die intravitreale operative Medikamentengabe (IVOM) von Vascular-endothelial-growth-factor (VEGF)-Inhibitoren, im klinischen Alltag umgesetzt wird. Im Rahmen einer internationalen retrospektiven Studie wurden(More)
Zielsetzung. In einer prospektiven Analyse wurden die angiographischen Befunde von Pigmentepithelabhebungen bei AMD differenziert. Es sollte festgestellt werden, ob Charakteristika einer “polypoidal choroidal vasculopathy” als Ursache für eine PE-Abhebung auch bei älteren Patienten mit mitteleuropäischem Hintergrund zu beobachten sind. Patienten und(More)