Martin R. Brown

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The problems associated with training feedforward artificial neural networks (ANNs) such as the multilayer perceptron (MLP) network and radial basis function (RBF) network have been well documented. The solutions to these problems have inspired a considerable amount of research, one particular area being the application of evolutionary search algorithms(More)
Trying to model the rainfall-runoff process is a complex activity as it is influenced by a number of implicit and explicit factors--for example, precipitation distribution, evaporation, transpiration, abstraction, watershed topography, and soil types. However, this kind of forecasting is particularly important as it is used to predict serious flooding,(More)
Cardiovascular toxicity is a prominent reason for failures in drug development, resulting in the demand for assays that can predict this liability in early drug discovery. We investigated whether iCell® cardiomyocytes have utility as an early QT/TdP screen. Thirty clinical drugs with known QT/TdP outcomes were evaluated blind using label-free microelectrode(More)
Significant prolonged AHR activation, classically exhibited following exposure to TCDD (dioxin), can cause a variety of undesirable toxicological effects. Novel pharmaceutical chemistries also have the potential to cause activation of AHR and consequent toxicities in pre-clinical species and man. Previous methods either employed relatively expensive and low(More)
Intensivist Training Programs and Standardization of Care In response to the recent guest editorial that discussed intensivist training programs and outcomes for critically ill patients, I agree there is a need for further education of those responsible for care of the critically ill. Perhaps the answer to this dilemma is to employ acute care nurse(More)
Activation and proliferation of resident cardiac progenitor cells has therapeutic potential to repair the heart after injury. However, research has been impeded by a lack of well-defined and characterized cell sources and difficulties in translation to screening platforms. Here, we describe the development, validation, and use of a 384-well phenotypic assay(More)
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