Martin Quibell

Learn More
2,4-Dimethoxy-1-(methylsulfanyl)benzene 5 To a solution of 6-hydroxy-1,3-benzoxathiol-2-one (purchased Aldrich CAS 4991-65-5) (16.82 g, 100 mmol) in 2-butanone (250 mL) was added cesium carbonate (73.05 g, 220 mmol) and iodomethane (70.97 g, 500 mmol) and the mixture was refluxed under nitrogen overnight. After cooling to room temperature the solid was(More)
A backbone amide bond protecting group, 2-hydroxy-4-methoxy-5-nitrobenzyl (Hmnb), improved the synthesis of aggregation and aspartimide-prone peptides. Introduction of Hmnb is automated and carried out during peptide assembly by addition of 4-methoxy-5-nitrosalicylaldehyde to the peptidyl-resin and on-resin reduction to the secondary amine. Acylation of the(More)
We have developed a convenient method for the direct synthesis of peptide thioesters, versatile intermediates for peptide ligation and cyclic peptide synthesis. The technology uses a modified Boc SPPS strategy that avoids the use of anhydrous HF. Boc in situ neutralization protocols are used in combination with Merrifield hydroxymethyl resin and TFA/TMSBr(More)
  • 1