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We present a novel texture compression system for improved image quality. Building on the iPACKMAN/ETC method, bit combinations that are invalid in that system are used to allow for three additional decompression modes without increasing the bit rate. These modes increase quality, especially for color edges and blocks with smoothly varying content. Due to(More)
Reducing the generation of amyloid-β (Aβ) in the brain via inhibition of β-secretase or inhibition/modulation of γ-secretase has been pursued as a potential disease-modifying treatment for Alzheimer's disease. For the discovery and development of β-secretase inhibitors (BACEi), γ-secretase inhibitors (GSI), and γ-secretase modulators (GSM), Aβ in(More)
A parametric packet-based model has been created to estimate user perceived audiovisual quality of Internet Protocol Television (IPTV) services. It is divided into three modules, for audio, video and audiovisual quality. The model is applicable to the quality monitoring of encrypted and non-encrypted audiovisual streams. Typical audio and video degradations(More)
In this paper, a novel method to detect scene changes in encrypted video streams is presented. Typically, in IPTV systems, the media stream is transmitted in encrypted form, and therefore the only available information to determine the scene changes are the packet headers which transport the video signal. Thus, the proposed method estimates the size and the(More)
The perceived quality of a multimedia stream can be estimated with good accuracy with a parametric no-reference opinion model taking codec, total coded bitrate, packet loss rate, and buffering events as input. A rebuffering event in a multimedia stream severely reduces the perceived quality with up to 1.5 MOS units for a QCIF video. High packet loss rates(More)
This article provides a tutorial overview of current approaches for monitoring the quality perceived by users of IP-based audiovisual media services. The article addresses both mobile and fixed network services such as mobile TV or Internet Protocol TV (IPTV). It reviews the different quality models that exploit packet- header-, bit stream-, or(More)
BACKGROUND AND OBJECTIVE Peri-implantitis is a destructive inflammatory process characterized by destruction of the implant-supporting bone. Inflammasomes are large intracellular multiprotein complexes that play a central role in innate immunity by activating the release of proinflammatory cytokines. Although inflammasome activation has previously been(More)
This paper describes the concept and a number of system aspects for the Dependent Random Access Point (DRAP) picture, a new feature that was recently introduced in the High-Efficiency Video Coding (HEVC) standard. A DRAP picture is an inter-coded picture that may only reference the previous Intra Random Access Point (IRAP) picture and provides a random(More)
The concise, enantioselective total syntheses of (-)-citrinadin A and (+)-citrinadin B in a total of only 20 and 21 steps, respectively, from commercially available starting materials are described. Our strategy, which minimizes refunctionalization and protection/deprotection operations, features the highly diastereoselective, vinylogous Mannich addition of(More)