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Yeast cAMP-dependent protein kinase (PKA) activity is essential for growth and antagonizes induction of the general stress response as well as accumulation of glycogen stores. Previous studies have suggested that the PKA effects on the two latter processes result in part from transcription repression. Here we show that transcription derepression that(More)
The Drosophila single-minded and trachealess bHLH-PAS genes control transcription and development of the CNS midline cell lineage and tracheal tubules, respectively. We show that Single-minded and Trachealess activate transcription by forming dimers with the Drosophila Tango protein that is an orthologue of the mammalian Arnt protein. Both cell culture and(More)
Yeast cyclic AMP (cAMP)-dependent protein kinase (PKA) activity is essential for growth and cell cycle progression. Dependence on PKA function can be partially relieved by overexpression of a gene, SOK2, whose product has significant homology with several fungal transcription factors (StuA from Aspergillus nidulans and Phd1 from Saccharomyces cerevisiae)(More)
The Drosophila Single-minded and Tango basic-helix-loop-helix-PAS protein heterodimer controls transcription and embryonic development of the CNS midline cells, while the Trachealess and Tango heterodimer controls tracheal cell and salivary duct transcription and development. Expression of both single-minded and trachealess is highly restricted to their(More)
The Drosophila spineless (ss) gene encodes a basic-helix-loop-helix-PAS transcription factor that is required for proper specification of distal antennal identity, establishment of the tarsal regions of the legs, and normal bristle growth. ss is the closest known homolog of the mammalian aryl hydrocarbon receptor (Ahr), also known as the dioxin receptor.(More)
This paper describes the concept of language oriented programming which is a novel way of organising the development of a large software system, leading to a different structure for the finished product. The approach starts by developing a formally specified, domain-oriented, very high-level language which is designed to be well-suited to developing " this(More)
In this paper we will take a detailed look at a larger example of program analysis by transformation. We will be considering Algorithm 2.3.3.A from Knuth's \Fundamental Algorithms" Knuth (1968) (P.357) which is an algorithm for the addition of polynomials represented using four-directional links. Knuth (1974) describes this as having \a complicated(More)
There is a vast collection of operational software systems which are vitally important to their users, yet are becoming increasingly difficult to maintain, enhance and keep up to date with rapidly changing requirements. For many of these so called legacy systems the option of throwing the system away an rewriting it from scratch is not economically viable.(More)