Martin P. Vessey

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Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) is associated with an increased risk of peptic ulcer complications, but it is not clear whether some drugs are more likely than others to cause such complications. We compared previous use of NSAIDs in 1144 patients aged 60 and older admitted to hospitals in five large cities with peptic ulcer(More)
OBJECTIVES To compare outcome between intensive care units in Britain and Ireland both before and after adjustment for case mix with the American APACHE II method and to validate the American APACHE II method in Britain and Ireland. DESIGN Prospective, cohort study of consecutive admissions to intensive care units. SETTING 26 general intensive care(More)
A prospective study of acute cerebrovascular disease in a community of about 105,000 people is reported. The study protocol combined rapid clinical assessment of patients with accurate diagnosis of the pathological type of stroke by CT or necropsy, whether or not they were admitted to hospital. The study population was defined as those people who were(More)
OBJECTIVE To explore the epidemiology of uterovaginal and post-hysterectomy prolapse. DESIGN Cohort study. SETTING Seventeen large family planning clinics in England and Scotland. POPULATION 17,032 women who attended family planning clinics between 1968 and 1974, aged between 25 and 39 years at study entry. METHODS Annual follow up by interview,(More)
BACKGROUND The association between current use of oral contraceptives and increased risk of venous thromboembolism (VTE) has been firmly established. Although data-sheets for hormone replacement therapy (HRT) carry similar warnings as regards VTE, evidence of an association is inconclusive. We carried out a hospital-based case-control study to investigate(More)
Of 17 032 women taking part in the Oxford Family Planning Association contraceptive study, 4104 stopped using a birth control method to plan a pregnancy on a total of 6199 occasions. The influence of various factors on fertility in these women was assessed by measuring the time taken to give birth to a child. An appreciable inverse relation was observed(More)
OBJECTIVE To assess the effect on time to diagnosis of recurrence and on quality of life of transferring primary responsibility for follow up of women with breast cancer in remission from hospital to general practice. DESIGN Randomised controlled trial with 18 month follow up in which women received routine follow up either in hospital or in general(More)
The survival experience of 582 women with premenopausal breast cancer was examined to determine whether prognosis was related to body size or to demographic and reproductive factors. During the follow-up period 228 patients died and 18 emigrated or were lost to follow-up. Usual body weight, reported at the time of diagnosis, was a strong predictor of(More)
OBJECTIVE To determine the risks of hospitalisation for bleeding peptic ulcer with the current prophylactic aspirin regimens of 300 mg daily or less. DESIGN A case-control study with hospital and community controls. SETTING Hospitals in Glasgow, Newcastle, Nottingham, Oxford, and Portsmouth. SUBJECTS 1121 patients with gastric or duodenal ulcer(More)
OBJECTIVE To determine the prevalence of polycystic ovaries as identified by ultrasound in a group of young, postmenarcheal women in the normal population, and to investigate how polycystic ovaries are related to the spectrum of clinical and biochemical symptoms associated with the polycystic ovary syndrome (PCOS). DESIGN Cross-sectional observational(More)