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Huntington's disease (HD) is one of an increasing number of neurodegenerative disorders caused by a CAG/polyglutamine repeat expansion. Mice have been generated that are transgenic for the 5' end of the human HD gene carrying (CAG)115-(CAG)150 repeat expansions. In three lines, the transgene is ubiquitously expressed at both mRNA and protein level.(More)
Daughters and daughters-in-law of presently unmarried elders were studied longitudinally, and the data were analyzed to determine how two transitions in caregiving status affected the women of the younger generation. One transition compared noncaregivers who had become caregivers 1 year later ("caregiving entrants," n = 33) with continuing noncaregivers (n(More)
The dimensions by which adults of differing ages experience emotion were studied by self-administering questionnaires administered to older adults (n = 828) recruited from Elderhostel programs, middle-aged (ages 30-59) children of Elderhostel attenders (n = 231), and young adult (ages 18-29) subjects recruited from college classes or through Elderhostel(More)
The self-reports of 207 young-adult (ages 18-30), 231 middle-aged (ages 31-59), and 828 older-adult (age 60 and over) Ss were used to study the structure of affect. Affects were represented by terms included in various circumplex arrays of emotions as presented by previous investigators. A set of 46 affects was subjected to exploratory analysis, and a final(More)
A method for assessing affect states among older people with Alzheimer's disease was developed for use in a study designed to evaluate a special care unit for such residents of a nursing home. The 6-item Philadelphia Geriatric Center Affect Rating Scale was designed for the use of research and other staff in assessing positive affect (pleasure, interest,(More)
OBJECTIVE To develop an observational instrument that describes the ability of physical environments of institutional settings to address therapeutic goals for persons with dementia. METHODS A National Institute on Aging workgroup identified and subsequently revised items that evaluated exit control, maintenance, cleanliness, safety, orientation/cueing,(More)
The relationship between positive and negative events and emotional well-being for depressed and nondepressed residents of a nursing home and congregate housing care facility was examined. For 30 consecutive working days, each of 79 participants was presented with the Philadelphia Geriatric Center Positive and Negative Affect rating scales. Events during(More)
"Personal projects," as defined by B. R. Little (1983), were elicited from 600 community residents aged 70+, representing a broad range of health and illness. Factor analysis revealed 6 types of personal projects: activities of daily living, active recreation, other-oriented activities, intellectual activities, home planning, and spiritual moral activities.(More)