Martin Moravec

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Telomerase-mediated telomere elongation provides cell populations with the ability to proliferate indefinitely. Telomerase is capable of recognizing and extending the shortest telomeres in cells; nevertheless, how this mechanism is executed remains unclear. Here, we show that, in the fission yeast Schizosaccharomyces pombe, shortened telomeres are highly(More)
Colorectal cancer is among the most frequent malignancies in the economically developed part of the world including the Czech Republic. From the molecular biological point of view, the development of colorectal cancer is in most cases linked to the pathologically activated canonical Wnt signalling pathway. The aim of this review is to present this(More)
BACKGROUND The aim of our study was to evaluate the potential advantages of the left retroperitoneal (RP) approach for abdominal aortic surgery and compare the aortic exposure with the transperitoneal (TP) approach which is widely used. PATIENTS AND METHODS Total 55 consecutive patients who underwent elective aortic surgery between 1998 and 1999 were(More)
AIM The aim of this retrospective analysis was assessment of both patency and limb salvage rates of diabetic ischemic feet which underwent pedal bypass surgery within the period of 3 years. MATERIAL AND METHODS Authors evaluated 50 critically ischemic diabetic feet where the pedal bypass was indicated for limb salvage. Total 41 pedal bypasses were(More)