Martin Maeng Bjørklund

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RATIONALE Atherosclerosis can be achieved in animals by germline genetic engineering, leading to hypercholesterolemia, but such models are constrained to few species and strains, and they are difficult to combine with other powerful techniques involving genetic manipulation or variation. OBJECTIVE To develop a method for induction of atherosclerosis(More)
BACKGROUND Although disturbed flow is thought to play a central role in the development of advanced coronary atherosclerotic plaques, no causal relationship has been established. We evaluated whether inducing disturbed flow would cause the development of advanced coronary plaques, including thin cap fibroatheroma. METHODS AND RESULTS D374Y-PCSK9(More)
Diabetes is associated with an increased risk of atherosclerotic cardiovascular disease, but whether there is a direct and independent role for impaired glucose control in atherogenesis remains uncertain. We investigated whether diabetes with poor glycaemic control would accelerate atherogenesis in a novel pig model of atherosclerosis, the D374Y-PCSK9 +(More)
BACKGROUND AND AIM The metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) has been suggested as a proatherogenic molecule by its ability to locally increase insulin-like growth factor signaling. Stanniocalcin-2 (STC2) was recently discovered to be a potent inhibitor of PAPP-A activity, but has not previously been implicated in vascular(More)
Ryan M. Pedrigi, PhD*; Christian Bo Poulsen, MD*; Vikram V. Mehta, PhD; Niels Ramsing Holm, MD; Nilesh Pareek, MB, BChir, MA; Anouk L. Post, MSc; Ismail Dogu Kilic, MD; Winston A.S. Banya, MSc; Gianni Dall’Ara, MD; Alessio Mattesini, MD; Martin M. Bjørklund, MD; Niels P. Andersen, MD; Anna K. Grøndal, MD; Enrico Petretto, PhD; Nicolas Foin, PhD; Justin E.(More)
BACKGROUND Hypertension is a major risk factor for development of atherosclerotic cardiovascular disease (ASCVD). Although lowering blood pressure with antihypertensive drugs reduces the increased risk of ASCVD, residual increased risk still remains, suggesting that hypertension may cause chronic changes that promote atherosclerosis. Thus, we tested the(More)
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