The Bioconductor project is an initiative for the collaborative creation of extensible software for computational biology and bioinformatics. The goals of the project include: fostering collaborative… (More)

Maximum likelihood or restricted maximum likelihood (REML) estimates of the parameters in linear mixed-effects models can be determined using the lmer function in the lme4 package for R. As for most… (More)

We study and compare two types of connectionist learning methods for model-free regression problems: 1) the backpropagation learning (BPL); and 2) the projection pursuit learning (PPL) emerged in… (More)

The package copula (formerly nacopula) provides procedures for constructing nested Archimedean copulas in any dimensions and with any kind of nesting structure, generating vectors of random variates… (More)

The R package Rmpfr allows to use arbitrarily precise numbers instead of R’s double precision numbers in many R computations and functions. This is achieved by defining S4 classes of such numbers and… (More)

Apart from kernel estimators, there have been quite a few different approaches of “generalized splines” for density estimation. In the present paper, Maximum Penalized Likelihood (mpl) approaches are… (More)

Computer programming is an important component of statistics research and data analysis. This skill is necessary for using sophisticated statistical packages as well as for writing custom software… (More)

The management of time and holidays can prove crucial in applications that rely on historical data. A typical example is the aggregation of a data set recorded in different time zones and under… (More)