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A data assimilation technique is used with a simple but widely used marine ecosystem model to optimize poorly known model parameters. A thorough analysis of the a posteriori errors to be expected for the estimated parameters was carried out. The errors have been estimated by calculating the Hessian matrices for different problem formulations based on… (More)

- Martin Losch, Alistair Adcroft, JEAN-MICHEL CAMPIN

The advent of high precision gravity missions presents the opportunity to accurately measure variations in the distribution of mass in the ocean. Such a data source will prove valuable in state estimation and constraining general circulation models (GCMs) in general. However, conventional GCMs make the Boussinesq approximations, a consequence of which is… (More)

- V. Smetácek, Christine Klaas, +27 authors Dieter A. Wolf-Gladrow
- Nature
- 2012

Fertilization of the ocean by adding iron compounds has induced diatom-dominated phytoplankton blooms accompanied by considerable carbon dioxide drawdown in the ocean surface layer. However, because the fate of bloom biomass could not be adequately resolved in these experiments, the timescales of carbon sequestration from the atmosphere are uncertain. Here… (More)

- Martin Losch, Carl Wunsch
- 2003

The possibility of using topography in a state estimation context as a control parameter is explored in a linear barotropic shallow water model. Along with its adjoint, the model is used to systematically assess the influence of the depth field on the modeled circulation in a steady state. Sensitivity of the flow field to the topography is greater in a… (More)

- H-J Wilke, Ute Klaassen, +8 authors Siegfried Seeber
- Annals of oncology : official journal of the…
- 1996

BACKGROUND
In metastatic breast cancer patients who have had prior exposure to anthracyclines, single agents induce less than 15% and combination chemotherapy less than 20%-30% of objective responses. Therefore more active and tolerable salvage regimens are needed.
PATIENTS AND METHODS
Forty-three patients with advanced breast cancer pretreated with 1-5… (More)

[1] Stratospheric ozone depletion and emission of greenhouse gases lead to a trend of the southern annular mode (SAM) toward its high-index polarity. The positive phase of the SAM is characterized by stronger than usual westerly winds that induce changes in the physical carbon transport. Changes in the natural carbon budget of the upper 100 m of the… (More)

- E M Rossiter, William Stewart Agras, Martin Losch, Christy F Telch
- Behaviour research and therapy
- 1988

- Jean-François Lemieux, Dana A. Knoll, L. Bruno Tremblay, David M. Holland, Martin Losch
- J. Comput. Physics
- 2012

- Martin Losch, Annika Fuchs, Jean-François Lemieux, Anna Vanselow
- J. Comput. Physics
- 2014

The most common representation of sea ice dynamics in climate models assumes that sea ice is a quasi-continuous non-normal fluid with a viscousplastic rheology. This rheology leads to non-linear sea ice momentum equations that are notoriously difficult to solve. Recently a Jacobian-free NewtonKrylov (JFNK) solver was shown to solve the equations accurately… (More)

7 Experiments with idealized geometry are used to compare model solutions of implicit VPand explicit EVP-solvers in two very different ice-ocean codes: the regular-grid, finite-volume Massachusetts Institute of Technology general circulation model (MITgcm) and the Alfred Wegener Institute Finite Element Ocean Model (FEOM). It is demonstrated that for both… (More)