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Understanding retinol metabolism: structure and function of retinol dehydrogenases.

• Martin Lidén, Ulf Eriksson
• The Journal of biological chemistry
• 2006

Retinoids (vitamin A derivatives) have dual functions in physiology. 11-cisRetinal serves as the universal chromophore of the visual pigments in the eye, and the hormonal retinoids, mainly… (More)

Structure and function of retinol dehydrogenases of the short chain dehydrogenase/reductase family.

• Martin Lidén, K. Tryggvason, Ulf Eriksson
• Molecular aspects of medicine
• 2003

All-trans-retinol is the common precursor of the active retinoids 11-cis-retinal, all-trans-retinoic acid (atRA) and 9-cis-retinoic acid (9cRA). Genetic and biochemical data supports an important… (More)

Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes.

• Anita Ost, Anna Danielsson, Martin Lidén, Ulf Eriksson, Fredrik H Nystrom, Peter Strålfors
• FASEB journal : official publication of the…
• 2007

Reduced sensitivity to insulin in adipose, muscle, and liver tissues is a hallmark of type 2 diabetes. Animal models and patients with type 2 diabetes exhibit elevated levels of circulating… (More)

The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function.

• Martin Lidén, K. Tryggvason, Ulf Eriksson
• Experimental cell research
• 2005

Retinoic acid is generated from retinol (vitamin A) by the sequential actions of two different classes of enzymes, retinol dehydrogenases and retinal dehydrogenases. Several enzymes implicated in… (More)

Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin.

• Steven E. Applequist, Erik N Rollman, +4 authors H G Ljunggren
• Journal of immunology
• 2005

Improving DNA vaccination remains a fundamental goal in vaccine research. Theoretically, this could be achieved by molecules encoded by DNA capable of activating TLRs to mimic inflammatory responses… (More)

Development of a versatile reporter assay for studies of retinol uptake and metabolism in vivo.

• Martin Lidén, Ulf Eriksson
• Experimental cell research
• 2005

The two isomers of retinoic acid (RA), all-trans RA and 9-cis RA, are produced in several tissues in order to allow specific control of target gene transcription. Given the high potency of these… (More)

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