Martin Langes

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GvHD is a major complication of allogeneic hematopoietic stem cell transplantation (aHSCT), and is mediated by cytotoxic T cells (CTLs), recruited by chemokines such as CXCL9/MIG, CXCL10/IP-10 and CXCL11/ITAC to target organs, where they effect tissue injury. B-cell contribution to GvHD pathogenesis is widely accepted, but only partially explained. The role(More)
Essential thrombocythemia (ET) patients are at risk of developing thrombotic events. Qualitative platelet (PLT) abnormalities and activation of endothelial cells (ECs) and PLTs are thought to be involved. Microparticles (MPs) can originate from PLTs (PMPs), ECs (EMPs), or red cells (RMPs). Previous studies have indicated that MPs contribute to ET(More)
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