Martin Kuehne

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The ATM protein, which is mutated in individuals with ataxia telangi-ectasia (AT), is central to cell cycle checkpoint responses initiated by DNA double-strand breaks (DSBs). ATM's role in DSB repair is currently unclear as is the basis underlying the radiosensitivity of AT cells. We applied immunofluorescence detection of ␥-H2AX nuclear foci and(More)
OBJECTIVE The iboga alkaloids are a class of small molecules defined structurally on the basis of a common ibogamine skeleton, some of which modify opioid withdrawal and drug self-administration in humans and preclinical models. These compounds may represent an innovative approach to neurobiological investigation and development of addiction(More)
Immunofluorescence detection of gammaH2AX foci is a widely used tool to quantify the induction and repair of DNA double-strand breaks (DSBs) induced by ionising radiation. We observed that X-irradiation of mammalian cells exposed on glass slides induced twofold higher foci numbers compared to irradiation with gamma-rays. Here, we show that the excess(More)
RADBIOPH-02 Toroidal electrostatic analyzer for double differential cross section for low energy 272 electron emission in solid foils RADBIOPH-07 PCNA dependent accumulation of p21 at heavy ion induced DNA lesions 277 RADBIOPH-09 Chromosome aberrations in pheripheral blood lymphocytes from patients with 279 primary prostate cancer before radiotherapy
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