Martin Kessler

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In preparing this document the Authors aimed to pool current information on canine and feline mast cell disease. The information was gathered from international studies and a emphasis was placed on material and opinion with a strong evidence base. We intend it to form the basis of our understanding in this disease at the current time and we anticipate that(More)
  • NICOLAS VÉRON, Zsolt Darvas, +7 authors Nicolas Véron
  • 2013
Highlights • New obstacles to the European banking union have emerged over the last year, but a successful transition remains both necessary and possible. The key next step will be in the second half of 2014, when the European Central Bank (ECB) will gain supervisory authority over most of Europe' s banking system. This needs to be preceded by a rigorous(More)
This prospective study aimed to record the toxicity profile of a dose-intensifying simultaneous chemotherapy (DISC) protocol for lymphoma in dogs. Remission rates and the duration of the protocol were also evaluated. Twenty-one dogs were studied. Diagnosis was based on cytological or histological assessments. The DISC protocol is a 13-week maintenance-free(More)
This study evaluated efficacy and side effects of masitinib in canine epitheliotropic lymphoma. Complete remission occurred in 2 of 10 dogs and lasted for median 85 days. Five dogs went into partial remission for median 60.5 days. Three pretreated dogs did not respond to therapy. Side effects occurred in six dogs and were mostly mild to moderate.(More)
This study describes clinical aspects, treatment, and survival times of 52 dogs with hemangiosarcoma of the spleen, presented at the Department of Veterinary Surgery, University of Munich, Germany. Depending on the dissemination of the disease the dogs were assigned to three clinical stages: 10 dogs were in stage I (tumor confined to the spleen without(More)
Tyrosine kinase inhibitors (TKIs) that specifically target cKIT represent a therapeutic approach for non-resectable canine mast cell tumours (MCTs) grade II/III. The therapeutic benefit of TKIs has been investigated in other tumours based on clinical response rates and identification of gain-of-function mutations. In the present study, cKIT expression in 14(More)
The multidrug resistance gene 1(MDR1) expression levels were analysed in 27 dogs with different types of malignant lymphomas receiving a standard chemotherapy protocol. Blood samples were used for MDR1 real-time PCR expression analysis. Treatment tolerance and outcome were evaluated on a regular basis by clinical examination and client questioning. Dogs(More)
Fine needle aspiration cytology is considered an adequate method fulfilling the requirements for an early, minimal invasive, and simple to perform diagnostic technique for malignancies. Its establishment in human medicine is the basis for propagation of this method in veterinary medicine. This paper describes the technique of performing a fine needle(More)
OBJECTIVE Retrospective evaluation of clinical findings in 33 dogs with tonsillar squamous cell carcinomas. MATERIAL AND METHODS At the owners' request 9 patients were euthanized after diagnosis. 24 treated patients were grouped into six categories depending on the type of therapy: 1. tonsillectomy and NSAID (Piroxicam or Metacam) (n=10); 2.(More)