Martin J. Rink

Learn More
Cdc25 phosphatases activate the cell division kinases throughout the cell cycle. The 2.3 A structure of the human Cdc25A catalytic domain reveals a small alpha/beta domain with a fold unlike previously described phosphatase structures but identical to rhodanese, a sulfur-transfer protein. Only the active-site loop, containing the Cys-(X)5-Arg motif, shows(More)
Human pp60c-src is a cellular nonreceptor tyrosine kinase that participates in cytosolic signal transduction and has been implicated in the development of malignant tumors in the human breast and colon. Signal transduction is mediated by highly specific interactions between the SH2 domain and receptor phosphorylated tyrosine binding motifs. To elucidate the(More)
A rapid method is described for the identification of organisms directly from blood culture broths, using antisera to group specific antigens and various commercially available serological and biochemical reagents. The technique identified clinically significant organisms within 1 to 3 h of a positive signal in the BACTECTM blood culture system. The method(More)
  • 1