Martin J. Pinter

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Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, 8 45435. 9 Department of Physiology, Emory University, Atlanta, GA, 30322 10 11 Corresponding author: 12 Timothy C. Cope 13 Department of Neuroscience, Cell Biology & Physiology 14 Wright State University School of Medicine 15 3640 Colonel Glenn Hwy 16 Dayton OH(More)
Fixed and diffusible calcium (Ca) buffers shape the spatial and temporal distribution of free Ca following Ca entry through voltage-gated ion channels. This modeling study explores intracellular Ca levels achieved near the membrane and in deeper locations following typical Ca currents obtained with patch clamp experiments. Ca ion diffusion sets an upper(More)
The relations among passive membrane properties have been examined in cat motoneurones utilizing exclusively electrophysiological techniques. A significant relation was found to exist between the input resistance and the membrane time constant. The estimated electrotonic length showed no evident tendency to vary with input resistance but did show a tendency(More)
In rats treated with high-dose corticosteroids, skeletal muscle that is denervated in vivo (steroid-denervated [S-D]) develops electrical inexcitability similar to that seen in patients with acute quadriplegic myopathy. In studies of affected muscles in vitro, the majority of S-D fibers failed to generate action potentials in response to intracellular(More)
Long after a cut peripheral nerve reinnervates muscle and restores force production in adult cats, the muscle does not respond reflexively to stretch. Motivated by the likelihood that stretch areflexia is related to problems with sensing and controlling limb position after peripheral neuropathies, we sought to determine the underlying mechanism.(More)
Long C3-C5 propriospinal neurones (PNs) are classified in 3 types depending on their pyramidal and vestibular input. The first type of PNs received pyramidal excitation but lacked vestibular effects. The second type of PNs was excited from the medial vestibular nucleus but not from the pyramid. The third type of PNs was excited from the lateral vestibular(More)
Intracellular recording was made in the C3-C5 segments of cats from cells identified as long propriospinal neurones (PNs) by antidromic activation from the lower thoracic segments. The cell bodies were in laminae VII and VIII and their ventrally located axons were either uncrossed or crossed. Stimulation of higher motor centres revealed monosynaptic(More)
Critical illness myopathy is an acquired disorder in which skeletal muscle becomes electrically inexcitable. We previously demonstrated that inactivation of Na+ channels contributes to inexcitability of affected fibres in an animal model of critical illness myopathy in which denervated rat skeletal muscle is treated with corticosteroids (steroid denervated;(More)
The Ca(2+) dependence of synaptic quantal release is generally thought to be restricted to probability of vesicular release. However, some studies have suggested that the number of release sites (n) at the neuromuscular junction (NMJ) is also Ca(2+) dependent. In this study, we recorded endplate currents over a wide range of extracellular Ca(2+)(More)
Hereditary canine spinal muscular atrophy is an autosomal dominant version of motor neuron disease in which motor units exhibit extensive dysfunction before motor terminal or axonal degeneration appear. We showed in a previous paper that motor endplate currents (EPCs) are reduced and that failures of nerve-evoked EPCs appear in the homozygote medial(More)