Martin Holmes

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The encapsulation of intact rat femoral head cartilage or discs of bovine nasal cartilage with cotton-gauze before implantation in the subcutaneous tissues of mice, results in an accelerated loss of cartilage proteoglycan. Loss of proteoglycan from bovine nasal cartilage occurred later than rat femoral head cartilage, but eventually brought about complete(More)
PURPOSE To determine the causes of visual impairment and blindness amongst children in schools for the blind in Myanmar; to identify the avoidable causes of visual impairment and blindness; and to provide spectacles, low vision aids, orientation and mobility training and ophthalmic treatment where indicated. METHODS Two hundred and eight children under 16(More)
Structures consistent in size, shape and character with various stages of a Lentivirus replicative cycle were observed by electron microscopy in 12-day peripheral-blood lymphocyte cultures from 10 of 17 Chronic Fatigue Syndrome patients and not in controls. Attempts to identify a lymphoid phenotype containing these structures by immunogold labelling failed(More)
PURPOSE To identify the causes of blindness and severe visual impairment (BL/SVI) in children attending four schools for the blind in Cambodia and to provide spectacles, low vision aids, orientation and mobility training and ophthalmic treatment. METHODS Children < 16 years of age were recruited from all 4 schools for the blind in Cambodia. Causes of(More)
After five months of total isolation a wintering party of seventeen British Antarctic Survey (BAS) personnel was inoculated under double blind concitions with placebo, or rhinovirus type 2 which had been propagated in tissue culture. The clinical and virological responses of these subjects were compared with those of volunteers in England who received a(More)
In this chapter, the authors examine the issue of digital formats for document encoding, archiving and publishing, through the specific example of “born-digital” scholarly journal articles. This small area of electronic publishing represents a microcosm of the state of the art, and provides a good basis for this discussion. The authors will begin by looking(More)
Thirteen men wintering on an Antarctic base were isolated from other human contact for 10 months. During this period Coxsackievirus A21 and later influenza A2 virus were administered to some of the men. Serum samples were collected from each of the men at monthly intervals.Coxsackievirus A21 produced symptoms and apparently spread to uninoculated men. It(More)
A series of meatal swabs, taken from 17 men over a period of 17 months during their tour at an Antarctic base was examined for mycoplasmas. The number of organisms isolated never exceeded 10(4) and not every specimen from each man yielded mycoplasmas. Nevertheless, Mycoplasma hominis was isolated from 71% and T-mycoplasmas from 59% of the men at some time(More)
This book constitutes the thoroughly refereed post-proceedings of the 10th International Workshop on Declarative Agent Languages and Technologies, DALT 2012, held in conjunction with the 11th International Joint Conference on Autonomous Agents and Multiagent Systems (AAMAS 2012) at Valencia, Spain, in June 2012. The volume contains 13 revised selected(More)
An antibody dependent cellular cytotoxic (ADCC) reaction was elicited using human mixed lymphocyte cultures against coronavirus 229E-infected C-16 cells. The response was assayed in microtitre plates by radioactive chromium release. Optimal killing of target cells was achieved using cells labelled 22 h after infection. A prozone was present and the optimal(More)