Martin Hofmann-Apitius

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MOTIVATION Chemical compounds like small signal molecules or other biological active chemical substances are an important entity class in life science publications and patents. Several representations and nomenclatures for chemicals like SMILES, InChI, IUPAC or trivial names exist. Only SMILES and InChI names allow a direct structure search, but in(More)
Speculative statements communicating experimental findings are frequently found in scientific articles, and their purpose is to provide an impetus for further investigations into the given topic. Automated recognition of speculative statements in scientific text has gained interest in recent years as systematic analysis of such statements could transform(More)
Chemical compounds like small signal molecules or other biological active chemical substances are an important entity class in life science publications and patents. The recognition of these named entities relies on appropriate dictionary resources as well as on training and evaluation corpora. In this work we give an overview of publicly available chemical(More)
A significant amount of information about drug-related safety issues such as adverse effects are published in medical case reports that can only be explored by human readers due to their unstructured nature. The work presented here aims at generating a systematically annotated corpus that can support the development and validation of methods for the(More)
WISDOM is an international initiative to enable a virtual screening pipeline on a Grid infrastructure. Its first attempt was to deploy large scale in silico docking on a public Grid infrastructure. Protein–ligand docking is about computing the binding energy of a protein target to a library of potential drugs using a scoring algorithm. Previous deployments(More)
The Gene Mention task is a Named Entity Recognition (NER) task for labeling gene and gene product names in biomedical text. To deal with acceptable alternatives additionally to the gold standard, we use combinations of Conditional Random Fields (CRF) together with a normalizing tagger. This process is followed by a postprocessing step including an acronym(More)
Despite continuous efforts of the international community to reduce the impact of malaria on developing countries, no significant progress has been made in the recent years and the discovery of new drugs is more than ever needed. Out of the many proteins involved in the metabolic activities of the Plasmodium parasite, some are promising targets to carry out(More)
INTRODUCTION MicroRNAs (miRNAs) have demonstrated their potential as post-transcriptional gene expression regulators, participating in a wide spectrum of regulatory events such as apoptosis, differentiation, and stress response. Apart from the role of miRNAs in normal physiology, their dysregulation is implicated in a vast array of diseases. Dissection of(More)
Electronic patient health records encompass valuable information about patient’s medical problems, diagnoses, and treatments offered including their outcomes. However, a problem for medical professionals is an ability to efficiently access the information that are documented in the form of free-text. Therefore, the work presented here exhibits an(More)
Posttranslational modifications of histones influence the structure of chromatine and in such a way take part in the regulation of gene expression. Certain histone modification patterns, distributed over the genome, are connected to cell as well as tissue differentiation and to the adaption of organisms to their environment. Abnormal changes instead(More)