Martin Healey

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OBJECTIVE To compare reduction of pain following laparoscopy after ablation or excision of endometriosis. DESIGN A prospective, randomized, double-blind study. SETTING Endometriosis and pelvic pain clinic at a university teaching hospital. PATIENT(S) Women of reproductive age presenting with pelvic pain and visually proved endometriosis. (More)
INTRODUCTION AND HYPOTHESIS This study assesses the prevalence of interstitial cystitis (IC)/bladder pain syndrome (BPS) in women with chronic pelvic pain (CPP). METHODS This was a prospective study of 150 women undergoing laparoscopy as investigation for CPP in an Endometriosis and Pelvic Pain unit. Preoperative questionnaires [demographic details,(More)
OBJECTIVE To assess the effects on patient discomfort of an intraabdominal passive gas drain left for four hours postoperatively following gynaecologic laparoscopic surgery. DESIGN A prospective randomised double-blinded placebo controlled trial. SETTING University tertiary hospital and private hospital. POPULATION OR SAMPLE Eighty women having a(More)
STUDY OBJECTIVE To compare reduction of pain after laparoscopy for ablation or excision of endometriosis. DESIGN Prospective, randomized, double-blind study (Canadian Task Force classification I). SETTING Endometriosis and pelvic pain clinic at a university teaching hospital. PATIENTS Women of reproductive age with pelvic pain and visually proved(More)
The medical records of all women who underwent hysterectomy for benign disease performed between 1986 and 1995 were reviewed to ascertain the incidence of morbidity and mortality of abdominal, vaginal, and laparoscopically assisted vaginal hysterectomy at a university teaching hospital. A total of 1940 hysterectomies were performed during this period; 74%(More)
Genome-wide association studies (GWAS) have identified markers within the WNT4 region on chromosome 1p36.12 showing consistent and strong association with increasing endometriosis risk. Fine mapping using sequence and imputed genotype data has revealed strong candidates for the causal SNPs within these critical regions; however, the molecular pathogenesis(More)
An open prospective observational study was performed, aiming to measure symptom severity following operative gynaecological laparoscopy and explore any associated factors. Women having concomitant procedures were excluded. Each woman had standardized analgesia, completed a symptom diary for 7 days postoperation, and had a standardized form completed by the(More)
To date, the quest to develop a noninvasive diagnostic test for endometriosis has mostly concentrated on the levels of cytokines and growth factors that are involved in inflammation, angioneogenesis and tissue remodeling, present in serum, peritoneal fluid, endometrium and endometriotic lesions. As this has not yet translated into the development of such a(More)
We establish a mortar boundary element scheme for hypersingular boundary integral equations representing elliptic boundary value problems in three dimensions. We prove almost quasi-optimal convergence of the scheme in broken Sobolev norms of order 1/2. Sub-domain decompositions can be geometrically non-conforming and meshes must be quasi-uniform only on(More)
STUDY QUESTION Do DNA variants in the growth regulation by estrogen in breast cancer 1 (GREB1) region regulate endometrial GREB1 expression and increase the risk of developing endometriosis in women? SUMMARY ANSWER We identified new single nucleotide polymorphisms (SNPs) with strong association with endometriosis at the GREB1 locus although we did not(More)