Martin Hartmann

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In a large collaborative screening project, 370 men with idiopathic azoospermia or severe oligozoospermia were analysed for deletions of 76 DNA loci in Yq11. In 12 individuals, we observed de novo microdeletions involving several DNA loci, while an additional patient had an inherited deletion. They were mapped to three different subregions in Yq11. One(More)
We introduce an open source software utility to extract the highly variable ITS1 and ITS2 subregions from fungal nuclear ITS sequences, the region of choice for environmental sampling and molecular identification of fungi. Inclusion of parts of the neighbouring, very conserved, ribosomal genes in the sequence identification process regularly leads to(More)
Chronic intrathecal immunoglobulin (Ig) production is a hallmark of multiple sclerosis characterized by the presence of oligoclonal IgGs and, in addition, polyspecific recognition of different pathogens such as measles, rubella and herpes zoster virus. While the antigen specificity of the oligoclonal IgGs in multiple sclerosis is largely unknown, the(More)
While the importance of viral infections is well studied in domestic cats, only limited information is available on their occurence and prevalence in the European wildcat (Felis silvestris silvestris). The aim of this study was to determine the prevalence of antibodies to feline coronavirus (FCoV), calicivirus (FCV), herpesvirus (FHV), parvovirus (FPV),(More)
Blood plasma samples from HIV-1-infected persons contain elevated glutamate concentrations up to 6-fold the normal level and relatively low concentrations of acid-soluble thiol (i.e. decreased cysteine concentrations). The intracellular glutathione concentration in peripheral blood-mononuclear cells (PBMC) and monocytes from HIV antibody-positive persons(More)
Porous silica materials have extensively been used for the immobilization of enzymes aiming at their use as biocatalysts or biosensors. This tutorial review will discuss the benefits and challenges of different immobilization techniques and will provide references to recent papers for further reading. Moreover, novel trends and unsolved problems will be(More)
The exquisite tactile sensing ability of biological whiskers has recently led to increasing interest in constructing robotic versions with similar capabilities. Tactile extraction of three-dimensional (3-D) object shape poses several unique challenges that have only begun to be addressed. The present study develops a method for estimating the contact(More)
We report our experience in using Guglielmi electrolytically detachable coils (GDC) alone or in combination with other materials in the treatment of intracranial or cervical high-flow fistulae. We treated 14 patients with arteriovenous fistulae on brain-supplying vessels – three involving the external carotid or the vertebral artery, five the cavernous(More)
Als Hashimoto-Enzephalopathie wird eine steroid-sensitive, schubförmig oder stetig progrediente Enzephalopathie bezeichnet, welche mit einer Hashimoto-Thyreoiditis assoziiert ist. Charakteristische klinische Befunde sind Verwirrtheit, epileptische Anfälle, Vigilanzminderung, schlaganfallähnliche Episoden, Myoklonien und Tremor. Die Liquordiagnostik zeigt(More)
Our aim was to determine whether CT angiography is suitable for the evaluation of in-stent restenoses in small vessel stents for intracranial angioplasty. Therefore, we simulated stenoses with degrees of 25, 50, 75 and 90% in a total of 12 stents with different designs (MEDTRONIC AVE; ABBOT BioDivYsio, GUIDANT Neurolink, TERUMO Tsunami, COOK V-Flex Plus)(More)