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Transcription profiling experiments permit the expression levels of many genes to be measured simultaneously. Given profiling data from two types of samples, genes that most distinguish the samples (marker genes) are good candidates for subsequent in-depth experimental studies and developing decision support systems for diagnosis, prognosis, and monitoring.(More)
—In this paper, a simple control method is presented for a single-stage single-switch isolated power-factor-correction (PFC) regulator that can simultaneously achieve unity power factor and fast output voltage regulation while keeping the voltage stress of the storage capacitor low. The converter topology comprises essentially a cascade combination of a(More)
SPARC (Secreted Protein that is Acidic and Rich in Cysteine) is a Ca2+-binding, stress-related protein released in vitro by both malignant and normal cells derived from all primordial germ layers. It is specifically elevated in endothelial cells as a result of "culture shock" (characterized by high levels of proliferation and migration) and exhibits(More)
A modular framework is proposed for modeling and understanding the relationships between molecular profile data and other domain knowledge using a combination of generative (here, graphical models) and discriminative [Support Vector Machines (SVMs)] methods. As illustration, naive Bayes models, simple graphical models, and SVMs were applied to published(More)
Low lethality treatment of the NIH 3T3 mouse cell line with methotrexate (MTX) during exponential multiplication results in heterogeneous, heritable reduction in growth rate of most if not all the replicatively surviving cells. The effective concentrations of MTX are 10 to 100 times higher in molecular, cellular and developmental biology medium 402 (MCDB(More)
— This paper studies a particular single-stage power-factor-correction (PFC) switching regulator employing a discontinuous-conduction-mode (DCM) boost-input cell and a continuous-current-mode (CCM) forward output cell. Although this single-stage PFC regulator can provide a reasonably high power factor when its PFC stage is operating in discontinuous mode,(More)
—This paper discusses a systematic method for deriving basic converter configurations that achieve power factor correction (PFC) and voltage regulation. The discussion begins with a general three-port representation of power supplies that provide PFC and voltage regulation. Based on this representation and a power flow consideration, a systematic procedure(More)
Recent clonal studies of spontaneous neoplastic transformation in cell culture indicate that it develops at confluence in a small minority of individual clonal populations before it does in the uncloned parental culture. Either preferential selection of spontaneous variants or genetic destabilization in clones can be inferred to explain the result. In the(More)
—This paper discusses a systematic method for deriving basic converter configurations that achieve power factor correction (PFC) and voltage regulation. The discussion begins with a general three-port representation of power supplies that provide PFC and voltage regulation. Based on this representation and a power flow consideration, a systematic procedure(More)