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Generating, grouping, and labeling free-sketch data is a difficult and time-consuming task for both user study participants and researchers. To simplify this process for both parties, we would like to have users draw isolated shapes instead of complete sketches that must be hand-labeled and grouped, and then use this data to train our free-sketch symbol(More)
Photoactivatable fluorescent proteins (FPs) are powerful fluorescent highlighters in live cell imaging and offer perspectives for optical nanoscopy and the development of biophotonic devices. Two types of photoactivation are currently being distinguished, reversible photoswitching between fluorescent and nonfluorescent forms and irreversible(More)
The fluorescent protein KillerRed generates reactive oxygen species through the CALI effect. This property paves the way for the design of genetically encoded photosensitizers for use in cell killing and cancer photodynamic therapy. In this article, we have investigated the diffusion pathways of di-oxygen and the superoxide radical in KillerRed, using(More)
In an introductory Engineering course with an annual enrollment of over 1000 students, a professor has little option but to rely on multiple choice exams for midterms and finals. Furthermore, the teaching assistants are too overloaded to give detailed feedback on submitted homework assignments. We introduce Mechanix, a computer-assisted tutoring system for(More)
Technology has been largely employed in the modern education system but rarely fosters natural communication between the human and the machine. We wish to explore the use of sketch recognition based software as a medium for student computer interaction within the context of computer assisted tutoring systems. Since the student can draw directly on the(More)
Proteins exist as a dynamic ensemble of interconverting substates, which defines their conformational energy landscapes. Recent work has indicated that mutations that shift the balance between conformational substates (CSs) are one of the main mechanisms by which proteins evolve new functions. In the present study, we probe this assertion by examining(More)
GestureCommander is a touch-based gesture control system for mobile devices that is able to recognize gestures as they are being performed. Continuous recognition allows the system to provide visual feedback to the user and to anticipate user commands to possibly decrease perceived response time. To achieve this goal we employ two Hidden Markov Model (HMM)(More)
Crowded classrooms and overworked professors are common at large universities, especially in lower-level introductory courses. To ease the grading workload of the professors in Engineering 111, and to aid in individualized learning of the student, we created Mechanix. Mekanix is a sketch recognition software package that can that can recognize, correct, and(More)
Mechanix is a sketch recognition tool that provides an efficient means for engineering students to learn how to draw truss free-body diagrams (FBDs) and solve truss problems. The system allows students to sketch these FBDs into a tablet computer or by using a mouse just as they would by hand, a mouse can also be used to draw the sketch using a regular(More)