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Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease
In patients with Alzheimer's disease (AD) and in a triple transgenic (3xTgAD) mouse model of AD low glucose metabolism in the brain precedes loss of memory and cognitive decline. The metabolism ofExpand
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Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization.
Although most cases of Alzheimer's disease (AD) are sporadic, ∼5% of cases are genetic in origin. These cases, known as familial Alzheimer's disease (FAD), are caused by mutations that alter the rateExpand
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  • Open Access
An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans
AbstractIn response to carbohydrate deprivation or prolonged fasting the ketone bodies, β-hydroxybutyrate (βHB) and acetoacetate (AcAc), are produced from the incomplete β-oxidation of fatty acids inExpand
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  • Open Access
Oral administration of a Ketone Ester regulates blood cholesterol in rats and humans
Control of cholesterol in Type 2 Diabetics and Pre-diabetics has been problematic as statins increase blood glucose. We propose that a unique β-hydroxybutyrate (βHB) Ester can provide non-lipogenic...