Martin F. Kemper
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Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease
- R. Pawlosky, Martin F. Kemper, Yoshihero Kashiwaya, M. T. King, M. Mattson, R. Veech
- Medicine, Biology
- Journal of neurochemistry
- 1 April 2017
In patients with Alzheimer's disease (AD) and in a triple transgenic (3xTgAD) mouse model of AD low glucose metabolism in the brain precedes loss of memory and cognitive decline. The metabolism of… Expand
Familial Alzheimer's disease mutations differentially alter amyloid β-protein oligomerization.
- M. Gessel, S. Bernstein, Martin F. Kemper, D. Teplow, M. Bowers
- Chemistry, Medicine
- ACS chemical neuroscience
- 21 November 2012
Although most cases of Alzheimer's disease (AD) are sporadic, ∼5% of cases are genetic in origin. These cases, known as familial Alzheimer's disease (FAD), are caused by mutations that alter the rate… Expand
An Ester of β-Hydroxybutyrate Regulates Cholesterol Biosynthesis in Rats and a Cholesterol Biomarker in Humans
- Martin F. Kemper, Shireesh Srivastava, M. Todd King, K. Clarke, R. Veech, R. Pawlosky
- Medicine, Chemistry
- 26 October 2015
AbstractIn response to carbohydrate deprivation or prolonged fasting the ketone bodies, β-hydroxybutyrate (βHB) and acetoacetate (AcAc), are produced from the incomplete β-oxidation of fatty acids in… Expand
Oral administration of a Ketone Ester regulates blood cholesterol in rats and humans
Control of cholesterol in Type 2 Diabetics and Pre-diabetics has been problematic as statins increase blood glucose. We propose that a unique β-hydroxybutyrate (βHB) Ester can provide non-lipogenic...