Martin F. McDermott

Learn More
The pathologies of many infectious, autoimmune and malignant diseases are influenced by the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T cells. Interindividual differences in cytokine profiles appear to be due, at least in part, to allelic polymorphism within regulatory regions of cytokine gene. Many studies have(More)
Class II major histocompatibility (MHC) molecules have an immunoregulatory role. These cell-surface glycoproteins present fragments of protein antigens (or peptides) to thymus-derived lymphocytes (T cells). Nucleotide sequence polymorphism in the genes that encode the class II MHC products determines the specificity of the immune response and is correlated(More)
Within the past few years, the focus on cytokine single nucleotide polymorphism (SNP) function and association with human diseases has increased considerably. This third supplement to the Cytokine Gene Polymorphism in Human Disease: On-line database describes the positive associations of cytokine SNPs in human diseases described in articles published from(More)
GS-7340 and GS-9131 {9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-propyl]adenine and 9-(R)-4'-(R)-[[[(S)-1-[(ethoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-2'-fluoro-1'-furanyladenine, respectively} are novel alkylalaninyl phenyl ester prodrugs of tenofovir {9-R-[(2-phosphonomethoxy)propyl]adenine} (TFV) and a(More)
Predictions for the diffractive photoproduction of the Υ-family at HERA energies, within the framework of the analysis by Frankfurt, Koepf and Strikman, are presented. Two novel effects lead to a significant enhancement of the original calculation: the non-diagonal (or skewed) kinematics, calculated to leading-log(Q 2) accuracy, and the large magnitude of(More)
We derive the major characteristics of inclusive and diffractive final states in Deep Inelastic Scattering off heavy nuclei for the high energy (small x) kinematics in which the limit of complete absorption is reached for the dominant hadronic fluctuations in the virtual photon (the black body limit of the process). Both the longitudinal and transverse(More)
An analysis of Deeply Virtual Compton Scattering (DVCS) is made within the colour dipole model. We compare and contrast two models for the dipole cross-section which have been successful in describing structure function data. Both models agree with the available cross section data on DVCS from HERA. We give predictions for various azimuthal angle(More)
executIve summary The Telecommunications Act of 1996 opened competition in the telecommunications market in the U.S. and forced the incumbent telecommunications companies to open both their physical and logical infrastructure for Competitive Local Exchange Carriers (CLECs). In this case study we focus on the problems that face a CLEC with regard to(More)