Martin Edwards

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Carbon tetrachloride (CCl4) is a classical pericentral hepatotoxicant; however, precise details of its mechanism of action remain unknown. One possibility is that Kupffer cells participant in this mechanism since CCl4 elevates calcium, and the release of toxic eicosanoids and cytokines by Kupffer cells is calcium-dependent. Therefore, these studies were(More)
Replicative DNA synthesis in normal human fibroblasts was inhibited by 50% when they were X-irradiated (8 Gy) and made permeable 30 min later, whereas only a slight inhibition (20%) was observed in similarly treated ataxia-telangiectasia cells. Treatment of irradiated normal cells with caffeine (2 mM) before permeabilization reversed the inhibitory effects(More)
Objective and Design: The ability of interleukin-4 (IL-4) to modulate activation of the transcription factors, NF-κB and STAT6, reduce proinflammatory cytokine expression and protect against liver injury induced by ischemia/ reperfusion was assessed.¶Materials and Subjects: C57BL/6 mice underwent 90 minutes of partial hepatic ischemia followed by 1 or 8 h(More)
Ectonucleotidases are membrane-bound or secreted proteins that hydrolyze extracellular nucleotides.  Recently, we identified three ectonucleotidases that hydrolyze extracellular adenosine 5'-monophosphate (AMP) to adenosine in primary somatosensory neurons.  Currently, it is unclear which ectonucleotidases hydrolyze ATP and ADP in these neurons. (More)
Three lines of epithelial-like cells have been developed from the renal cortices of pigs of known histocompatibility type; the cells have been shown to stimulate the development of cytotoxicity in allogenic lymphocytes cultured in contact with them. For this stimulation to occur, it was necessary for the lymphocytes to be of a type that would show(More)
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