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This article presents the methodology that has been successfully used over the past seven years by an interdisciplinary team to create the International Committee for Documentation of the International Council of Museums (CIDOC) CONCEPTUAL REFERENCE MODEL (CRM), a high-level ontology to enable information integration for cultural heritage data and their(More)
BACKGROUND The study objective was to examine changes in prognosis and treatment of prostate cancer patients over 20 years and to evaluate their impact on survival. PATIENTS AND METHODS 38,861 prostate cancer patients diagnosed between 1990 and 2010 and living in the catchment area of the Munich Cancer Registry were analysed. RESULTS Pre-therapeutic(More)
In this paper, we argue that a core ontology is one of the key building blocks necessary to enable the scalable assimilation of information from diverse sources. A complete and extensible ontology that expresses the basic concepts that are common across a variety of domains and can provide the basis for specialization into domain-specific concepts and(More)
OBJECTIVE This paper introduces the objectives, methods and results of ontology development in the EU co-funded project Advancing Clinico-genomic Trials on Cancer-Open Grid Services for Improving Medical Knowledge Discovery (ACGT). While the available data in the life sciences has recently grown both in amount and quality, the full exploitation of it is(More)
This paper elaborates on the problem of modeling provenance for both physical and digital objects. In particular it discusses provenance according to OAIS (ISO 14721:2003) and how it relates with the conceptualization of CIDOC CRM ontology (ISO 21127:2006). Subsequently it introduces an extension of the CIDOC CRM ontol-ogy, able to capture the modeling and(More)
Decades of research have been devoted to the goal of creating systems which integrate information into a global knowledge network, yet we still face problems of cross-repository interoperability, lack of public infrastructure, and a coherent research agenda—both theoretical and practical—to face these challenges. Interest in the semantic Web has(More)
The tutorial first addresses requirements and semantic problems to integrate digital information into large scale, meaningful networks of knowledge that support not only access to source documents but also use and reuse of integrated information. The pros and cons of developing global ontologies are discussed. It is argued that core ontologies of(More)
An essential matter in heterogeneous database integration is the mapping process. In this report we present a mapping language for information integration under a common knowledge representation model (LAV approach). Based on particular requirements for a sufficient quality of information integration to be achieved, we present the most common cases of(More)