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OBJECTIVE The 2010 Survey of High Impact Psychosis (SHIP) is Australia's second national psychosis survey. This paper provides an overview of its findings, including comparisons with the first psychosis survey and general population data. METHODS The survey covered 1.5 million people aged 18-64 years, approximately 10% of Australians in this age group. A(More)
OBJECTIVE To quantify the direct and indirect effects of fetal life, childhood, and adult life on risk of cardiovascular disease at age 49-51 years. DESIGN Follow up study of the "Newcastle thousand families" birth cohort established in 1947. PARTICIPANTS 154 men and 193 women who completed a health and lifestyle questionnaire and attended for clinical(More)
We present the discovery of debris systems around three solar mass stars based upon observations performed with the Spitzer Space Telescope as part of a Legacy Science Program, " the Formation and Evolution of Planetary Systems " (FEPS). We also confirm the presence of debris around two other stars. All the stars exhibit infrared emission in excess of the(More)
Whilst case formulation is a critical task in psychiatry, it is an unexplored area in the field of medical expert systems development, which has mostly focused on the diagnostic inference. Case formulation plays a more important role in planning, and individualising treatments compared to categorical diagnoses. Nevertheless, case formulation is considered(More)
OBJECTIVE Psychiatric formulation is often considered a challenging task, particularly for trainees and students in psychiatry. The process of arriving at a good psychiatric formulation involves identifying major issues of the patient, and developing an explanatory system, which can be derived using known theoretical models in psychiatry. A good explanatory(More)
Understanding of the neurophysiological basis of cognitive, behavioural and perceptual disturbances associated with long-term cannabis use has grown dramatically. Exogenous cannabinoids alter the normative functioning of the endogenous cannabinoid system. This system is an important regulator of neurotransmission. Recent research has demonstrated(More)
Epidemiological data link adolescent cannabis use to psychosis and schizophrenia, but its contribution to schizophrenia neuropathology remains controversial. First-episode schizophrenia (FES) patients show regional cerebral grey- and white-matter changes as well as a distinct pattern of regional grey-matter loss in the vermis of the cerebellum. The(More)
Most published epidemiology studies of long-term air pollution health effects have relied on central site monitoring to investigate regional-scale differences in exposure. Few cohort studies have had sufficient data to characterize localized variations in pollution, despite the fact that large gradients can exist over small spatial scales. Similarly,(More)
Cerebellar dysfunction has been proposed to lead to "cognitive dysmetria" in schizophrenia via the cortico-cerebellar-thalamic-cortical circuit, contributing to a range of cognitive and clinical symptoms of the disorder. Here we investigated total cerebellar grey and white matter volumes and cerebellar regional grey matter abnormalities in 13 remitted(More)