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Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis.

• Martin Chopra, Simone S. Riedel, +14 authors Andreas Beilhack
• Carcinogenesis
• 2013

The cytokine tumor necrosis factor (TNF) has pleiotropic functions both in normal physiology and disease. TNF signals by the virtue of two cell surface receptors, TNF receptor 1 (TNFR1) and TNF… (More)

Characterization of ochratoxin A-induced apoptosis in primary rat hepatocytes

• Martin Chopra, Pascal Link, Christine Michels, Dieter Schrenk
• Cell Biology and Toxicology
• 2009

The main target organ of the mycotoxin ochratoxin A (OTA) in mammals is the kidney but OTA has also been shown to be hepatotoxic in rats and to induce tumors in mouse liver. Even at very low… (More)

Dioxin toxicity, aryl hydrocarbon receptor signaling, and apoptosis-persistent pollutants affect programmed cell death.

• Martin Chopra, Dieter Schrenk
• Critical reviews in toxicology
• 2011

Exogenous ligands of the aryl hydrocarbon receptor (AhR) such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and related substances are highly toxic pollutants ubiquitously present in the environment.… (More)

Inhibition of UV-C light-induced apoptosis in liver cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

• Martin Chopra, Arunasalam M Dharmarajan, Gregor Meiss, Dieter Schrenk
• Toxicological sciences : an official journal of…
• 2009

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic pollutant ubiquitously present in the environment. Most of the toxic effects of TCDD are believed to be mediated by high-affinity binding… (More)

A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo.

• Johannes Trebing, Isabell Lang, +8 authors Harald Wajant
• mAbs
• 2014

Expression of fibroblast growth factor (FGF)-inducible 14 (Fn14), a member of the tumor necrosis factor receptor superfamily, is typically low in healthy adult organisms, but strong Fn14 expression… (More)

A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model

• Carina A. Bäuerlein, Simone S. Riedel, +11 authors Andreas Beilhack
• BMC medicine
• 2013

BACKGROUND Acute graft-versus-host disease (aGVHD) poses a major limitation for broader therapeutic application of allogeneic hematopoietic cell transplantation (allo-HCT). Early diagnosis of aGVHD… (More)

Interleukin-2 critically regulates bone marrow erythropoiesis and prevents anemia development.

• Martin Chopra, Daniela Langenhorst, Andreas Beilhack, E. Serfling, Amiya Kumar Patra
• European journal of immunology
• 2015

Mice deficient in IL-2 signaling develop severe anemia indicating a defect in erythropoiesis. However, why deficiency in IL-2, an essential growth factor for lymphocytes, or in IL-2 signaling… (More)

Non-Invasive Bioluminescence Imaging to Monitor the Immunological Control of a Plasmablastic Lymphoma-Like B Cell Neoplasia after Hematopoietic Cell Transplantation

• Martin Chopra, Sabrina Kraus, +6 authors Andreas Beilhack
• PloS one
• 2013

To promote cancer research and to develop innovative therapies, refined pre-clinical mouse tumor models that mimic the actual disease in humans are of dire need. A number of neoplasms along the B… (More)

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

• Martin Chopra, Marlene Biehl, +33 authors Andreas Beilhack
• The Journal of experimental medicine
• 2016

Donor CD4(+)Foxp3(+) regulatory T cells (T reg cells) suppress graft-versus-host disease (GvHD) after allogeneic hematopoietic stem cell transplantation (HCT [allo-HCT]). Current clinical study… (More)

Selective NFAT targeting in T cells ameliorates GvHD while maintaining antitumor activity.

• Martin Vaeth, Carina A. Bäuerlein, +6 authors Friederike Berberich-Siebelt
• Proceedings of the National Academy of Sciences…
• 2015

Graft-versus-host disease (GvHD) is a life-threatening immunological complication after allogenic hematopoietic stem cell transplantation (allo-HCT). The intrinsic graft-versus-leukemia (GvL) effect,… (More)

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