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BACKGROUND Human glutamic acid decarboxylase 65 (hGAD65) is a key autoantigen in type 1 diabetes, having much potential as an important marker for the prediction and diagnosis of type 1 diabetes, and for the development of novel antigen-specific therapies for the treatment of type 1 diabetes. However, recombinant production of hGAD65 using conventional(More)
Glucagon-like peptide-1 (GLP-1) is a small peptide hormone with potent insulinotropic activity and represents a promising new therapeutic tool for the treatment of diabetes. Like many other therapeutic peptides, GLP-1 is commonly produced using chemical synthesis methods, but is limited by product quantity and cost. The advent of recombinant DNA technology(More)
Patients who acquired an upper extremity nerve injury often complain about cold intolerance, reduced sensitivity and decreased task performance. This study tried to quantify these complaints and look in more detail at the thermal reaction to local cold exposure of the affected limb. We found that 36% of 107 subjects could be classified as cold intolerant.(More)
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