Martin Bialik

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Endoxifen, the most active metabolite of the prodrug tamoxifen, is produced by cytochrome P450 CYP2D6. Breast cancer patients treated with tamoxifen who have reduced CYP2D6 activity, related to either genetic variation or drug inhibition, may have inferior outcomes. To assess the effect of concomitant CYP2D6 inhibiting drug use on clinical outcomes of(More)
Evidence for the association between hypomagnesemia and proton pump inhibitors (PPIs), highlighted by the 2011 FDA Drug Safety Communication, rests mainly on studies in hospitalized patients. Our objectives were to determine the prevalence of hypomagnesemia and its association with PPIs in the community setting. We performed a retrospective cross-sectional(More)
BACKGROUND In controlled trials, dual therapy with angiotensin-converting enzyme inhibitors (ACE-I) and angiotensin receptor blockers (ARBs) is associated with hyperkalemia and decreased renal function, but there is no information about these adverse effects in clinical practice. OBJECTIVE The aim of this study was to assess the incidence of hyperkalemia(More)
OBJECTIVES To compare death rates of diabetic men and women relative to the general population and to identify sex-specific risk factors for all-cause mortality. STUDY DESIGN AND SETTINGS In the current historical prospective cohort study, standardized mortality ratios (SMRs) were calculated for 19,657 men and women with diabetes in a large Israeli health(More)
BACKGROUND In population studies, mild hypomagnesemia, determined by a single measurement, was associated with incident atrial fibrillation, over ~20 years of follow-up. We sought to determine whether mild (≤ 1.7 mg/dL) and moderate (≤ 1.5mg/dL) hypomagnesemia are temporally associated with increased incidence of atrial fibrillation (AF) in the community.(More)
Retinal detachment after cataract extraction occurred in nine out of 136 eyes with myopia of 6 or more dioptress (6-7 per cent), during a follow-up period of 1 1/2-9 1/2 years. Five of the nine detachments occurred within 3 months of cataract extraction. All patients with retinal detachment were under the age of 63 years. Relatively young patients with high(More)
To evaluate the association between levonorgestrel-releasing intrauterine system (LNG-IUS) use and breast cancer (BC) risk. A cohort of all Maccabi Healthcare Services (MHS) female members aged 40–50 years between 1/2003 and 12/2013 was used to identify LNG-IUS users as “cases,” and 2 age-matched non-users as “controls.” Exclusion criteria included: prior(More)
The behavior of parents may have a decisive impact on the child's adjustment to treatment. Their positive attitudes have a calming effect, support the patient's emotionally and overcome problems and bear sufferings involved in the treatment. Conversely, negative attitude may ruin the adjustment and provoke pessimism, lack of cooperation and even(More)
Peculiarities of adjustment of pediatric cancer patients and their perception of the disease were studied in a group of 29 including 12 cases of hematooncological diseases and 17 cases of different solid tumors. Projective psychological methods were used. Such menifestations of failure to adjust as lower selfesteem, feeling of guilt, helplessness,(More)
Nine cases are presented, six of them in detail, which suggest that there is a high risk of bullous keratopathy developing when the lens is removed for the treatment of acute glaucoma due to an intumescent cataract. In some cases the keratopathy is due to detachment of Descemet's membrane from the cornea. Acute glaucoma due to an intumescent cataract should(More)