Non-linear mixed effects (NLME) models represent a powerful tool to simultaneously analyse data from several individuals. In this study, a compartmental model of leucine kinetics is examined and extended with a stochastic differential equation to model non-steady-state concentrations of free leucine in the plasma. Data obtained from tracer/tracee… (More)
Language models that use interleaving, or shuffle, operators have applications in various areas of computer science, including system verification, plan recognition, and natural language processing. We study the complexity of the membership problem for such models, i.e., how difficult it is to determine if a string belongs to a language or not. In… (More)
We develop a formal perspective on how regular expression matching works in Java 1 , a popular representative of the category of regex-directed matching engines. In particular, we define an automata model which captures all the aspects needed to study such matching engines in a formal way. Based on this, we propose two types of static analysis, which take a… (More)
Exosomes are nano-sized vesicles released by cells into the extracellular space and have been shown to be present in thymic tissue both in mice and in humans. The source of thymic exosomes is however still an enigma and hence it is not known whether thymic epithelial cells (TECs) are able to produce exosomes. In this work, we have cultured human TECs and… (More)
Motivation: Context-free grammars cannot express all features of natural languages.
• Recall tree correction problem (Selkow) • Define a swap operation for trees and discuss the problem of integrating it in Selkow tree correction problems • Show that swaps in tree correction is intractable in general through a three step reduction Background: String edit distance
Parsing for mildly context-sensitive language formalisms is an important area within natural language processing. While the complexity of the parsing problem for some such formalisms is known to be polynomial, this is not the case for all of them. This article presents a series of results regarding the complexity of parsing for linear context-free rewriting… (More)
CONTEXT Mathematical models may help the analysis of biological systems by providing estimates of otherwise un-measurable quantities such as concentrations and fluxes. The variability in such systems makes it difficult to translate individual characteristics to group behavior. Mixed effects models offer a tool to simultaneously assess individual and… (More)