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OBJECTIVE To investigate the role of hippocampal plasticity in the antidepressant effect of electroconvulsive therapy (ECT). METHOD We used magnetic resonance (MR) imaging including diffusion tensor imaging (DTI) and proton MR spectroscopy (1 H-MRS) to investigate hippocampal volume, diffusivity, and metabolite changes in 19 patients receiving ECT for(More)
BACKGROUND Depression has been associated with increased oxidative stress and hypothesized to accelerate aging. Nucleic acid damage from oxidation is a critical part of the aging process, and a suggested early event in age-related somatic morbidities that are also prevalent in depression, such as dementia and type 2 diabetes. We hypothesized that increased(More)
The cellular localization of adenosine A1 receptors in the CA1 region of the rat hippocampus was investigated using radioligand binding and lesioning methods in a quantitative autoradiographic study. Kainic acid injection reduced [3H]cyclohexyladenosine binding in the CA3 region by 40% and in the CA1 region by 30%. Transient cerebral ischemia reduced(More)
Any given single nucleotide polymorphism (SNP) in a genome may have little or no functional impact. A biologically significant effect may possibly emerge only when a number of key SNP-related genotypes occur together in a single organism. Thus, in analysis of many SNPs in association studies of complex diseases, it may be useful to look at combinations of(More)