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- David E. F. Harrison, Randy Strong, +11 authors Richard L. Miller
- Nature
- 2009
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR… (More)
- Richard L. Miller, David E. F. Harrison, +15 authors Randy Strong
- The journals of gerontology. Series A, Biological…
- 2011
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test… (More)
- Bankole A Johnson, Nassima Ait-Daoud, +5 authors Jennie Z Ma
- Lancet
- 2003
BACKGROUND
Topiramate, a sulphamate fructopyranose derivative, might antagonise alcohol's rewarding effects associated with abuse liability by inhibiting mesocorticolimbic dopamine release via the… (More)
- Saloua Benmansour, Marco Cecchi, +4 authors Alan Frazer
- The Journal of neuroscience : the official…
- 1999
To investigate functional changes in the brain serotonin transporter (SERT) after chronic antidepressant treatment, several techniques were used to assess SERT activity, density, or its mRNA content.… (More)
- Richard L. Miller, David E. F. Harrison, +13 authors Randy Strong
- Aging cell
- 2014
Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our… (More)
- Marco Cecchi, Habibeh Khoshbouei, Martin A. Javors, David A Morilak
- Neuroscience
- 2002
The brain noradrenergic system is activated by stress, and modulates the activity of forebrain regions involved in behavioral and neuroendocrine responses to stress, such as the lateral bed nucleus… (More)
- Irwin Jon Russell, H Vaeroy, Martin A. Javors, Fredrik Nyberg
- Arthritis and rheumatism
- 1992
OBJECTIVE
To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.
METHODS
Metabolites of… (More)
- Remi-Martin Laberge, Yu Sun, +18 authors Judith Campisi
- Nature Cell Biology
- 2015
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse… (More)
- Bankole A Johnson, John D. Roache, +6 authors Johannes Hensler
- JAMA
- 2000
CONTEXT
Early-onset alcoholism differs from late-onset alcoholism by its association with greater serotonergic abnormality and antisocial behaviors. Thus, individuals with early-onset alcoholism may… (More)
- Yiqiang Zhang, Alex Bokov, +14 authors Kathleen Fischer
- The journals of gerontology. Series A, Biological…
- 2014
Target of rapamycin inhibition by rapamycin feeding has previously been shown to extend life in genetically heterogeneous mice. To examine whether it similarly affected mouse health, we fed… (More)