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- David E. F. Harrison, Randy Strong, +11 authors Richard A. Miller
- Nature
- 2009
Inhibition of the TOR signalling pathway by genetic or pharmacological intervention extends lifespan in invertebrates, including yeast, nematodes and fruitflies; however, whether inhibition of mTOR… (More)
- R. Allen Miller, David E. F. Harrison, +15 authors Randy Strong
- The journals of gerontology. Series A, Biological…
- 2011
Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test… (More)
- Bankole A Johnson, Nassima Ait-Daoud, +5 authors Jennie Z. Ma
- Lancet
- 2003
BACKGROUND
Topiramate, a sulphamate fructopyranose derivative, might antagonise alcohol's rewarding effects associated with abuse liability by inhibiting mesocorticolimbic dopamine release via the… (More)
- Richard A. Miller, David E. F. Harrison, +13 authors Randy Strong
- Aging cell
- 2014
Rapamycin, an inhibitor of mTOR kinase, increased median lifespan of genetically heterogeneous mice by 23% (males) to 26% (females) when tested at a dose threefold higher than that used in our… (More)
- I. Jon Russell, Henning Vaeroy, Martin A. Javors, Fred J Nyberg
- Arthritis and rheumatism
- 1992
OBJECTIVE
To compare the levels of biogenic amines in the cerebrospinal fluid (CSF) of primary fibromyalgia syndrome (PFS) patients with those in the CSF of controls.
METHODS
Metabolites of… (More)
- M. Cecchi, Habibeh Khoshbouei, Martin A. Javors, David A Morilak
- Neuroscience
- 2002
The brain noradrenergic system is activated by stress, and modulates the activity of forebrain regions involved in behavioral and neuroendocrine responses to stress, such as the lateral bed nucleus… (More)
- R Laberge, Yu Sun, +18 authors Judith Campisi
- Nature Cell Biology
- 2015
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse… (More)
- Yiqiang Zhang, Alex Bokov, +14 authors Kathleen Fischer
- The journals of gerontology. Series A, Biological…
- 2014
Target of rapamycin inhibition by rapamycin feeding has previously been shown to extend life in genetically heterogeneous mice. To examine whether it similarly affected mouse health, we fed… (More)
- Randy Strong, Richard A. Miller, +10 authors David E. F. Harrison
- Aging cell
- 2008
The National Institute on Aging's Interventions Testing Program was established to evaluate agents that are purported to increase lifespan and delay the appearance of age-related disease in… (More)
- W. Anthony Owens, Rajkumar J Sevak, +5 authors Lynette C. Daws
- Journal of neurochemistry
- 2005
Insulin affects brain reward pathways and there is converging evidence that this occurs through insulin regulation of the dopamine (DA) transporter (DAT). In rats made hypoinsulinemic by fasting,… (More)