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We developed a variety of 54-channel high-density silicon electrode arrays (polytrodes) designed to record from large numbers of neurons spanning millimeters of brain. In cat visual cortex, it was possible to make simultaneous recordings from >100 well-isolated neurons. Using standard clustering methods, polytrodes provide a quality of single-unit isolation(More)
In order to determine patterns of neural activity, spike signals recorded by extracellular electrodes have to be clustered (sorted) with the aim of ensuring that each cluster represents all the spikes generated by an individual neuron. Many methods for spike sorting have been proposed but few are easily applicable to recordings from polytrodes which may(More)
This paper compares the ability of different methods to detect and resolve spikes recorded extracellularly with polytrode and high-density microelectrode arrays (MEAs). Detecting spikes on such arrays is more complex than with single electrodes or tetrodes since a single spike from a neuron may cause threshold crossings on several adjacent channels, giving(More)
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