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We developed a variety of 54-channel high-density silicon electrode arrays (polytrodes) designed to record from large numbers of neurons spanning millimeters of brain. In cat visual cortex, it was possible to make simultaneous recordings from >100 well-isolated neurons. Using standard clustering methods, polytrodes provide a quality of single-unit isolation(More)
In order to determine patterns of neural activity, spike signals recorded by extracellular electrodes have to be clustered (sorted) with the aim of ensuring that each cluster represents all the spikes generated by an individual neuron. Many methods for spike sorting have been proposed but few are easily applicable to recordings from polytrodes which may(More)
encouraged us to standardize on Python for the spike sorting and spike train analysis projects to follow. For one of us (M. Spacek), the switch to Python has made programming a much more enjoyable and productive experience, and has resulted in greatly improved programming skills. The benefi ts of Python have been extolled at length elsewhere a powerful,(More)
Electrophysiology is increasingly moving towards highly parallel recording techniques which generate large data sets. We record extracellularly in vivo in cat and rat visual cortex with 54-channel silicon polytrodes, under time-locked visual stimulation, from localized neuronal populations within a cortical column. To help deal with the complexity of(More)
This paper compares the ability of different methods to detect and resolve spikes recorded extracellularly with polytrode and high-density microelectrode arrays (MEAs). Detecting spikes on such arrays is more complex than with single electrodes or tetrodes since a single spike from a neuron may cause threshold crossings on several adjacent channels, giving(More)
In chronic lymphocytic leukemia (CLL) the level of minimal residual disease (MRD) after therapy is an independent predictor of outcome. Given the increasing number of new agents being explored for CLL therapy, using MRD as a surrogate could greatly reduce the time necessary to assess their efficacy. In this European Research Initiative on CLL (ERIC) project(More)
BACKGROUND The use of multichannel electrode arrays (MEAs) presents a number of practical challenges to experimenters including correctly labelling different recording channel locations and identifying sites that may be non-functional or short-circuited. These challenges are likely to increase as the number of sites used in recording increases. NEW METHOD(More)
5 How does cortical state affect neural responses to naturalistic stimuli, and is it analogous be-6 tween anesthetized and awake animals? We recorded spikes and local field potential (LFP) in 7 isoflurane-anesthetized cat V1 while repeatedly presenting wide-field natural scene movie clips. 8 Spiking responses were remarkably precise, reliable and sparse.(More)