Martijn P. F. Berger

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BACKGROUND Pain is a common and major problem among nursing home residents. The prevalence of pain in elderly nursing home people is 40-80%, showing that they are at great risk of experiencing pain. Since assessment of pain is an important step towards the treatment of pain, there is a need for manageable, valid and reliable tools to assess pain in elderly(More)
OBJECTIVES To investigate the effects of an educational intervention on the use of physical restraints with psychogeriatric nursing home residents. DESIGN Cluster-randomized trial. SETTING Fifteen psychogeriatric nursing home wards in the Netherlands. PARTICIPANTS In total, 432 psychogeriatric nursing home residents from 15 psychogeriatric nursing(More)
In view of the need for valid, reliable, and clinically useful scales to assess pain in elderly people with dementia, this study evaluated the psychometric properties of translated versions of the PAINAD, PACSLAC, and DOLOPLUS-2 scales. In an observational study design, two raters simultaneously assessed the nursing home residents (n=128) for pain during(More)
BACKGROUND Studies on pain and pain prevalence in older people with dementia are limited compared to those on cognitively intact older people. Pain prevalence rates in older people with dementia are estimated to be between 28% and 83%. AIMS This study aimed to explore pain prevalence in nursing home residents with dementia using observational scale(More)
BACKGROUND Although there is an urgent need for restraint-free care, the number of randomized clinical trials on preventing or reducing physical restraints has been limited. OBJECTIVES To investigate the effectiveness of an educational intervention to prevent the use of physical restraints on residents newly admitted to psycho-geriatric nursing home(More)
PURPOSE Small bowel irradiation results in epithelial cell loss and consequently impairs function and metabolism. We investigated whether citrulline, a metabolic end product of small bowel enterocytes, can be used for quantifying radiation-induced epithelial cell loss. METHODS AND MATERIALS NMRI mice were subjected to single-dose whole body irradiation(More)
Subject-specific hemodynamic response functions (HRFs) have been recommended to capture variation in the form of the hemodynamic response between subjects (Aguirre et al., [ 1998]: Neuroimage 8:360-369). The purpose of this article is to find optimal designs for estimation of subject-specific parameters for the double gamma HRF. As the double gamma function(More)
In this paper we apply the genetic algorithm developed by Kao et al. (2009) to find designs which are robust against misspecification of the error autocorrelation. Two common optimality criteria, the A-optimality criterion and the D-optimality criterion, based upon a general linear model are employed to obtain locally optimal designs for a given value of(More)
PURPOSE Plasma citrulline, a nitrogen end product of glutamine metabolism in small-bowel enterocytes, was suggested as a marker of radiation-induced small-bowel epithelial cell loss in mice after single-dose whole-body irradiation. Our objective was to evaluate the feasibility of citrulline as a marker for radiation-induced small-intestinal mucosal atrophy(More)
This paper reports a study of the relationship between the use of physical restraints with psycho-geriatric nursing home residents and the characteristics of organisations and residents. It is hypothesised that impairment in residents and organisational characteristics, such as a high workload of nursing staff and a low full-time equivalent (FTE) ratio on(More)